PMID- 21050576
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20121002
LR  - 20101105
IS  - 1009-3419 (Print)
IS  - 1009-3419 (Linking)
VI  - 4
IP  - 4
DP  - 2001 Aug 20
TI  - [A random study on taxol and concomitant radiotherapy vs sequential combined 
      modality in treatment of advanced non-small cell lung cancer].
PG  - 268-71
LID - 10.3779/j.issn.1009-3419.2001.04.07 [doi]
AB  - BACKGROUND: To evaluate the results of taxol and concomitant radiotherapy and 
      those of sequential combined modality chemotherapy with taxol plus cisplatin ( 
      DDP) and radiotherapy in treatment of locally advanced non small cell lung cancer 
      ( NSCLC) . METHODS: From January 1998 through August 1999, 36 patients ( 24 male, 
      12 female; 18 squamous cell carcinoma, 14 adenocarcinoma, 4 others; 24 initially 
      treated, 12 retreated) with locally advanced NSCLC were enrolled in this study 
      and were randomized into 2 groups. The median age of the patients was 58. The 
      majority of patients had a performance status of 0 or 1. In concomitant group, 
      the patients received radiation therapy at 2 Gy given on Monday to Friday of each 
      week for 6 to 7 consecutive weeks. The total planned radiation dose was 60 to 65 
      Gy. At twenty-four hours before radiotherapy, taxol 40 mg / m(2) was administered 
      on Sunday of each week for 6 consecutive weeks. In sequential group, the patients 
      received induction chemotherapy with taxol 175 mg/ m(2) and cisplatin 100mg/ m(2) 
      every 3 weeks for two cycles followed by conventional radiation therapy. RESULTS: 
      The overall response rate was 66. 7% ( 12/ 18) in concomitant group and 50%( 9/ 
      18) in sequential group. The local control rate was 83. 3%( 15/ 18) in 
      concomitant group and 50% ( 9/ 18) in sequential group. The main toxicity in 
      concomitant group was esophagitis ( 72. 2%, 13/ 18) . The hematological tox icity 
      and other nonhematological toxicity were mild in concomitant group. The main 
      toxicities in sequential group were leukocytopenia ( 94. 4% , 17/ 18; grade 3/ 4 
      in 7 patients) , nausea and vomiting ( 94. 4%, 17/ 18; grade 3/ 4 in 5 patients) 
      , alopecia ( grade 3/ 4 in 8 patients) , neurotoxicity ( grade 1/ 2 in 14 
      patients) and nephrotoxicity ( grade 1/ 2 in 5 patients) . One year survival rate 
      in concomitant group was 50% ( 9/ 18) and in sequential group was 44. 4% ( 8/ 18) 
      . The median survival period was 12 months in concomitant group and 11 months in 
      sequential group. CONCLUSIONS: Weekly taxol and concomitant radiotherapy is as 
      effective as sequential combined modality in patients with locally advanced NSCLC 
      and concomitant chemoradiotherapy has higher local control rate and lower tox 
      icity except for esophagitis.
FAU - Zhang, X
AU  - Zhang X
AD  - Cancer Research And Treatment Center , Shandong Province Hospital , Jinan, 
      Shandong 250021, P. R . China.
FAU - Liu, F
AU  - Liu F
FAU - Qu, F
AU  - Qu F
FAU - Hong, S
AU  - Hong S
FAU - Shen, H
AU  - Shen H
FAU - Xu, G
AU  - Xu G
LA  - chi
PT  - English Abstract
PT  - Journal Article
PL  - China
TA  - Zhongguo Fei Ai Za Zhi
JT  - Zhongguo fei ai za zhi = Chinese journal of lung cancer
JID - 101126433
EDAT- 2001/08/20 00:00
MHDA- 2001/08/20 00:01
CRDT- 2010/11/06 06:00
PHST- 2010/11/06 06:00 [entrez]
PHST- 2001/08/20 00:00 [pubmed]
PHST- 2001/08/20 00:01 [medline]
AID - 10.3779/j.issn.1009-3419.2001.04.07 [doi]
PST - ppublish
SO  - Zhongguo Fei Ai Za Zhi. 2001 Aug 20;4(4):268-71. doi: 
      10.3779/j.issn.1009-3419.2001.04.07.