PMID- 21052009
OWN - NLM
STAT- MEDLINE
DCOM- 20120227
LR  - 20121115
IS  - 1533-4023 (Electronic)
IS  - 0160-2446 (Linking)
VI  - 57
IP  - 2
DP  - 2011 Feb
TI  - Myocardial fibrosis attenuates the effect of cibenzoline on left ventricular 
      diastolic function in patients with hypertrophic cardiomyopathy.
PG  - 207-12
LID - 10.1097/FJC.0b013e318203830d [doi]
AB  - The aim of this study was to investigate the relationship between late gadolinium 
      enhancement (LGE) and the effect of cibenzoline (CBZ) on left ventricular (LV) 
      diastolic function in hypertrophic cardiomyopathy (HCM) patients. 
      Echocardiography before and after intravenous CBZ (1.4 mg/kg over 5 minutes) and 
      magnetic resonance imaging (MRI) were performed in 22 consecutive patients with 
      HCM [mean age: 65 +/- 14 years, obstructive HCM: 14, nonobstructive HCM (HNCM): 8]. 
      The extent of LGE (%LGE = LGE volume/total LV volume) was obtained by 
      contrast-enhanced MRI using custom software. LGE was observed in 19 patients 
      (mean %LGE = 5.1% +/- 3.9%). The propagation velocity of LV early filling flow (Vp) 
      increased significantly in patients with obstructive HCM (26 +/- 7 to 36 +/- 14 cm/s, 
      P = 0.001) and nonobstructive HCM (25 +/- 9 to 36 +/- 16 cm/s, P = 0.007). A 
      significant negative correlation was observed between the change in Vp and %LGE 
      in patients with HCM (r = 20.542, P = 0.009). Less extensive myocardial fibrosis, 
      as demonstrated by LGE on contrast-enhanced MRI, may predict the ability of CBZ 
      to improve LV diastolic function in HCM.
FAU - Saito, Makoto
AU  - Saito M
AD  - Department of Cardiology, Kitaishikai Hospital, Ozu, Japan.
FAU - Okayama, Hideki
AU  - Okayama H
FAU - Yoshii, Toyofumi
AU  - Yoshii T
FAU - Hiasa, Go
AU  - Hiasa G
FAU - Sumimoto, Takumi
AU  - Sumimoto T
FAU - Inaba, Shinji
AU  - Inaba S
FAU - Nishimura, Kazuhisa
AU  - Nishimura K
FAU - Inoue, Katsuji
AU  - Inoue K
FAU - Ogimoto, Akiyoshi
AU  - Ogimoto A
FAU - Shigematsu, Yuji
AU  - Shigematsu Y
FAU - Funada, Jun-ichi
AU  - Funada J
FAU - Hamada, Mareomi
AU  - Hamada M
FAU - Higaki, Jitsuo
AU  - Higaki J
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PL  - United States
TA  - J Cardiovasc Pharmacol
JT  - Journal of cardiovascular pharmacology
JID - 7902492
RN  - 0 (Imidazoles)
RN  - Z7489237QT (cifenline)
SB  - IM
MH  - Cardiomyopathy, Hypertrophic/*drug therapy/*pathology/physiopathology
MH  - Diastole/drug effects/physiology
MH  - Female
MH  - Fibrosis
MH  - Humans
MH  - Imidazoles/pharmacology/*therapeutic use
MH  - Male
MH  - Middle Aged
MH  - Myocardium/*pathology
MH  - Ventricular Function, Left/*drug effects/*physiology
EDAT- 2010/11/06 06:00
MHDA- 2012/03/01 06:00
CRDT- 2010/11/06 06:00
PHST- 2010/11/06 06:00 [entrez]
PHST- 2010/11/06 06:00 [pubmed]
PHST- 2012/03/01 06:00 [medline]
AID - 10.1097/FJC.0b013e318203830d [doi]
PST - ppublish
SO  - J Cardiovasc Pharmacol. 2011 Feb;57(2):207-12. doi: 10.1097/FJC.0b013e318203830d.