PMID- 21052896
OWN - NLM
STAT- MEDLINE
DCOM- 20110204
LR  - 20221207
IS  - 1613-2246 (Electronic)
IS  - 0021-5155 (Linking)
VI  - 54
IP  - 5
DP  - 2010 Sep
TI  - Indocyanine green angiography findings in initial acute pretreatment 
      Vogt-Koyanagi-Harada disease in Japanese patients.
PG  - 377-82
LID - 10.1007/s10384-010-0853-6 [doi]
AB  - PURPOSE: Indocyanine green angiography (IA) is a highly sensitive method to 
      evaluate choroidal inflammatory lesions. We present standardized IA findings of 
      initial acute Vogt-Koyanagi-Harada (VKH) disease in Japanese patients before 
      therapeutical intervention. METHODS: Medical records of patients with VKH disease 
      at Tokyo Medical and Dental University Hospital and Miyata Eye Hospital were 
      retrospectively analyzed. We analyzed six IA signs: choroidal perfusion 
      inhomogeneity, early hyperfluorescent stromal vessels, hypofluorescent dark dots 
      (HDDs), fuzzy or lost pattern of large stromal vessels, disc hyperfluorescence, 
      and diffuse late choroidal hyperfluorescence. RESULTS: Ten patients from the two 
      hospitals were studied. The most constant findings present in all eyes were early 
      hyperfluorescent stromal vessels, HDDs, and either fuzzy or lost pattern of large 
      stromal vessels. Disc hyperfluorescence was present in 18 eyes. Choroidal 
      perfusion inhomogeneity was seen in six patients, and diffuse late choroidal 
      hyperfluorescence was seen to a certain degree in all eyes. CONCLUSIONS: Four of 
      the analyzed signs, including early hyperfluorescent stromal vessels, HDDs, fuzzy 
      or lost pattern of large stromal vessels, and disc hyperfluorescence were 
      consistent findings in Japanese VKH patients. Because the primary lesion is 
      situated in the choroid, IA is the method of choice to monitor disease activity 
      in VKH disease.
FAU - Miyanaga, Masaru
AU  - Miyanaga M
AD  - Department of Ophthalmology and Visual Science, Tokyo Medical and Dental 
      University Graduate School of Medical and Dental Sciences, Tokyo, Japan.
FAU - Kawaguchi, Tatsushi
AU  - Kawaguchi T
FAU - Miyata, Kazunori
AU  - Miyata K
FAU - Horie, Shintaro
AU  - Horie S
FAU - Mochizuki, Manabu
AU  - Mochizuki M
FAU - Herbort, Carl P
AU  - Herbort CP
LA  - eng
PT  - Journal Article
DEP - 20101105
PL  - Japan
TA  - Jpn J Ophthalmol
JT  - Japanese journal of ophthalmology
JID - 0044652
RN  - 0 (Coloring Agents)
RN  - IX6J1063HV (Indocyanine Green)
SB  - IM
MH  - Acute Disease
MH  - Adult
MH  - Aged
MH  - Asian People/ethnology
MH  - Choroid/blood supply
MH  - Choroiditis/diagnosis
MH  - *Coloring Agents
MH  - Female
MH  - *Fluorescein Angiography
MH  - Humans
MH  - *Indocyanine Green
MH  - Male
MH  - Middle Aged
MH  - Retinal Vessels/pathology
MH  - Uveomeningoencephalitic Syndrome/*diagnosis/ethnology
MH  - Young Adult
EDAT- 2010/11/06 06:00
MHDA- 2011/02/05 06:00
CRDT- 2010/11/06 06:00
PHST- 2010/01/12 00:00 [received]
PHST- 2010/04/26 00:00 [accepted]
PHST- 2010/11/06 06:00 [entrez]
PHST- 2010/11/06 06:00 [pubmed]
PHST- 2011/02/05 06:00 [medline]
AID - 10.1007/s10384-010-0853-6 [doi]
PST - ppublish
SO  - Jpn J Ophthalmol. 2010 Sep;54(5):377-82. doi: 10.1007/s10384-010-0853-6. Epub 
      2010 Nov 5.