PMID- 21054262
OWN - NLM
STAT- MEDLINE
DCOM- 20110411
LR  - 20211020
IS  - 1874-4745 (Electronic)
IS  - 1874-4737 (Print)
IS  - 1874-4737 (Linking)
VI  - 3
IP  - 3
DP  - 2010 Sep
TI  - An essential role for adenosine signaling in alcohol abuse.
PG  - 163-74
AB  - In the central nervous system (CNS), adenosine plays an important role in 
      regulating neuronal activity and modulates signaling by other neurotransmitters, 
      including GABA, glutamate, and dopamine. Adenosine suppresses neurotransmitter 
      release, reduces neuronal excitability, and regulates ion channel function 
      through activation of four classes of G protein-coupled receptors, A(1), A(2A), 
      A(2B), and A(3). Central adenosine are largely controlled by nucleoside 
      transporters, which transport adenosine levels across the plasma membrane. 
      Adenosine has been shown to modulate cortical glutamate signaling and 
      ventral-tegmental dopaminergic signaling, which are involved in several aspects 
      of alcohol use disorders. Acute ethanol elevates extracellular adenosine levels 
      by selectively inhibiting the type 1 equilibrative nucleoside transporter, ENT1. 
      Raised adenosine levels mediate the ataxic and sedative/hypnotic effects of 
      ethanol through activation of A(1) receptors in the cerebellum, striatum, and 
      cerebral cortex. Recently, we have shown that pharmacological inhibition or 
      genetic deletion of ENT1 reduces the expression of excitatory amino acid 
      transporter 2 (EAAT2), the primary regulator of extracellular glutamate, in 
      astrocytes. These lines of evidence support a central role for adenosine-mediated 
      glutamate signaling and the involvement of astrocytes in regulating ethanol 
      intoxication and preference. In this paper, we discuss recent findings on the 
      implication of adenosine signaling in alcohol use disorders.
FAU - Ruby, Christina L
AU  - Ruby CL
AD  - Department of Molecular Pharmacology and Experimental Therapeutics, Mayo Clinic 
      College of Medicine, 200 First Street SW, Rochester, Minnesota 55905, USA.
FAU - Adams, Chelsea A
AU  - Adams CA
FAU - Knight, Emily J
AU  - Knight EJ
FAU - Nam, Hyung Wook
AU  - Nam HW
FAU - Choi, Doo-Sup
AU  - Choi DS
LA  - eng
GR  - P20 AA017830/AA/NIAAA NIH HHS/United States
GR  - R01 AA015164/AA/NIAAA NIH HHS/United States
GR  - R01 AA018779/AA/NIAAA NIH HHS/United States
GR  - P20 AA017380/AA/NIAAA NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
PT  - Review
PL  - United Arab Emirates
TA  - Curr Drug Abuse Rev
JT  - Current drug abuse reviews
JID - 101468123
RN  - 0 (Nucleoside Transport Proteins)
RN  - 0 (Receptors, Purinergic P1)
RN  - 3K9958V90M (Ethanol)
RN  - K72T3FS567 (Adenosine)
SB  - IM
MH  - Adenosine/*metabolism
MH  - Alcohol Drinking/*metabolism
MH  - Alcoholic Intoxication/metabolism
MH  - Alcoholism/*metabolism
MH  - Animals
MH  - Astrocytes/metabolism
MH  - Brain/drug effects/metabolism
MH  - Ethanol/metabolism/pharmacology
MH  - Humans
MH  - Nucleoside Transport Proteins/metabolism
MH  - Receptors, Purinergic P1/metabolism
MH  - Signal Transduction
PMC - PMC3922619
MID - NIHMS546326
EDAT- 2010/11/09 06:00
MHDA- 2011/04/13 06:00
PMCR- 2014/02/12
CRDT- 2010/11/09 06:00
PHST- 2010/09/10 00:00 [received]
PHST- 2010/09/20 00:00 [accepted]
PHST- 2010/11/09 06:00 [entrez]
PHST- 2010/11/09 06:00 [pubmed]
PHST- 2011/04/13 06:00 [medline]
PHST- 2014/02/12 00:00 [pmc-release]
AID - CDAR ABS-16 [pii]
AID - 10.2174/1874473711003030163 [doi]
PST - ppublish
SO  - Curr Drug Abuse Rev. 2010 Sep;3(3):163-74. doi: 10.2174/1874473711003030163.