PMID- 2105500
OWN - NLM
STAT- MEDLINE
DCOM- 19900314
LR  - 20220311
IS  - 0027-8424 (Print)
IS  - 1091-6490 (Electronic)
IS  - 0027-8424 (Linking)
VI  - 87
IP  - 3
DP  - 1990 Feb
TI  - Heritable major histocompatibility complex class II-associated differences in 
      production of tumor necrosis factor alpha: relevance to genetic predisposition to 
      systemic lupus erythematosus.
PG  - 1233-7
AB  - We report on the production of tumor necrosis factor (TNF)-alpha and TNF-beta by 
      mitogen-activated peripheral blood lymphocytes or enriched monocyte 
      subpopulations from human leukocyte antigen (HLA)-typed healthy subjects. The 
      results indicate that HLA-DR2- and DQw1-positive donors frequently exhibit low 
      production of TNF-alpha, whereas DR3- and DR4-positive subjects show high levels 
      of TNF-alpha production. No correlation between TNF-alpha levels and HLA-A, -B, 
      and -C genotype was found. The relevance of this quantitative polymorphism to the 
      genetic predisposition to lupus nephritis in systemic lupus erythematosus (SLE) 
      patients was investigated. DR2, DQw1-positive SLE patients show low levels of 
      TNF-alpha inducibility; this genotype is also associated with an increased 
      incidence of lupus nephritis. DR3-positive SLE patients, on the other hand, are 
      not predisposed to nephritis, and these patients have high TNF-alpha production. 
      DR4 haplotype is associated with high TNF-alpha inducibility and is negatively 
      correlated with lupus nephritis. These data may help explain the strong 
      association between HLA-DR2, DQw1 in SLE patients and their susceptibility to 
      nephritis.
FAU - Jacob, C O
AU  - Jacob CO
AD  - Department of Microbiology and Immunology, Stanford University School of 
      Medicine, CA 94305-5402.
FAU - Fronek, Z
AU  - Fronek Z
FAU - Lewis, G D
AU  - Lewis GD
FAU - Koo, M
AU  - Koo M
FAU - Hansen, J A
AU  - Hansen JA
FAU - McDevitt, H O
AU  - McDevitt HO
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - Proc Natl Acad Sci U S A
JT  - Proceedings of the National Academy of Sciences of the United States of America
JID - 7505876
RN  - 0 (Lymphotoxin-alpha)
RN  - 0 (Tumor Necrosis Factor-alpha)
SB  - IM
MH  - Alleles
MH  - Female
MH  - *Genes, MHC Class I
MH  - *Genes, MHC Class II
MH  - Humans
MH  - Lupus Erythematosus, Systemic/genetics/*immunology
MH  - Lymphocyte Activation
MH  - Lymphocytes/immunology
MH  - Lymphotoxin-alpha/biosynthesis
MH  - Male
MH  - Pedigree
MH  - Reference Values
MH  - Tumor Necrosis Factor-alpha/*biosynthesis
PMC - PMC53445
EDAT- 1990/02/01 00:00
MHDA- 1990/02/01 00:01
PMCR- 1990/08/01
CRDT- 1990/02/01 00:00
PHST- 1990/02/01 00:00 [pubmed]
PHST- 1990/02/01 00:01 [medline]
PHST- 1990/02/01 00:00 [entrez]
PHST- 1990/08/01 00:00 [pmc-release]
AID - 10.1073/pnas.87.3.1233 [doi]
PST - ppublish
SO  - Proc Natl Acad Sci U S A. 1990 Feb;87(3):1233-7. doi: 10.1073/pnas.87.3.1233.