PMID- 21055028
OWN - NLM
STAT- MEDLINE
DCOM- 20110919
LR  - 20171116
IS  - 0529-5807 (Print)
IS  - 0529-5807 (Linking)
VI  - 39
IP  - 8
DP  - 2010 Aug
TI  - [Study on genetic aberrations of ocular mucosa-associated lymphoid tissue 
      lymphomas occurring in southern China].
PG  - 513-7
AB  - OBJECTIVE: To study the genetic aberrations of ocular extranodal marginal zone 
      B-cell lymphomas of mucosa-associated lymphoid tissue (MALT) type occurring in 
      patients from southern China. METHODS: Fifty seven paraffin-embedded ocular MALT 
      lymphoma specimens from patients in southern China were studied by interphase 
      fluorescence-in-situ hybridization (FISH) for genetic aberrations including 
      t(11;18)(q21;q21)/API2-MALT1, t(1;14)(p22;q32)/IgH-bcl-10, t(14;18) 
      (q32;q21)/IgH-MALT1 and bcl-6/FOXP1 gene translocations. RESULTS: Amongst the 57 
      cases studied, 9 cases (15.8%) showed chromosome translocations, including 4 
      cases (7.0%) of t(11;18)(q21;q21)/API2-MALT1, 1 case (1.8%) of t(14;18) 
      (q32;q21)/IgH-MALT1, 1 case (1.8%) of bcl-6 gene-related chromosome translocation 
      and 3 cases (5.3%) of IgH-unknown translocation partner. FISH revealed 17 cases 
      (29.8%) with 3 copies of bcl-6 gene, 21 cases (36.8%) with 3 copies of MALT1 gene 
      and 12 cases (21.1%) with 3 copies of both genes. CONCLUSIONS: The MALT 
      lymphoma-associated chromosome translocations t(11;18)(q21;q21)/API2-MALT1 and 
      t(14;18) (q32;q21)/IgH-MALT1 are demonstrated in ocular MALT lymphomas of 
      southern Chinese patients. The prevalence is significantly different from that 
      reported in northern Chinese and northern American patients, indicating a 
      geographic heterogeneity in the MALT lymphoma-associated genetic aberrations. The 
      presence of 3 copies of bcl-6 and MALT1 genes is the commonest genetic 
      abnormalities observed in ocular MALT lymphomas, suggesting a possible role in 
      MALT lymphomagenesis.
FAU - Zhang, Xue-mei
AU  - Zhang XM
AD  - Department of Pathology, the Fourth Affiliated Hospital, Guangxi Medical 
      University, Liuzhou, China.
FAU - Zhang, Wen-yan
AU  - Zhang WY
FAU - Zhou, Yuan-ping
AU  - Zhou YP
FAU - Mo, Xiang-lan
AU  - Mo XL
FAU - Li, Yong-ping
AU  - Li YP
FAU - Wang, Gui-qiu
AU  - Wang GQ
FAU - Zhou, Ying-qiong
AU  - Zhou YQ
FAU - Zeng, Si-en
AU  - Zeng SE
FAU - Li, Gan-di
AU  - Li GD
FAU - Ye, Hong-tao
AU  - Ye HT
LA  - chi
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - China
TA  - Zhonghua Bing Li Xue Za Zhi
JT  - Zhonghua bing li xue za zhi = Chinese journal of pathology
JID - 0005331
RN  - 0 (BCL6 protein, human)
RN  - 0 (DNA-Binding Proteins)
RN  - 0 (Neoplasm Proteins)
RN  - 0 (Proto-Oncogene Proteins c-bcl-6)
RN  - EC 3.4.22.- (Caspases)
RN  - EC 3.4.22.- (MALT1 protein, human)
RN  - EC 3.4.22.- (Mucosa-Associated Lymphoid Tissue Lymphoma Translocation 1 Protein)
SB  - IM
MH  - Caspases/genetics/metabolism
MH  - China
MH  - *Chromosome Aberrations
MH  - Chromosomes, Human, Pair 11/genetics
MH  - Chromosomes, Human, Pair 14/genetics
MH  - Chromosomes, Human, Pair 18/genetics
MH  - Chromosomes, Human, Pair 3/genetics
MH  - DNA-Binding Proteins/genetics/metabolism
MH  - Eye Neoplasms/*genetics/metabolism
MH  - Humans
MH  - In Situ Hybridization, Fluorescence
MH  - Lymphoma, B-Cell, Marginal Zone/*genetics/metabolism
MH  - Mucosa-Associated Lymphoid Tissue Lymphoma Translocation 1 Protein
MH  - Neoplasm Proteins/genetics/metabolism
MH  - Proto-Oncogene Proteins c-bcl-6
MH  - *Translocation, Genetic
MH  - Trisomy
EDAT- 2010/11/09 06:00
MHDA- 2011/09/20 06:00
CRDT- 2010/11/09 06:00
PHST- 2010/11/09 06:00 [entrez]
PHST- 2010/11/09 06:00 [pubmed]
PHST- 2011/09/20 06:00 [medline]
PST - ppublish
SO  - Zhonghua Bing Li Xue Za Zhi. 2010 Aug;39(8):513-7.