PMID- 21055329
OWN - NLM
STAT- MEDLINE
DCOM- 20110203
LR  - 20161125
IS  - 1673-0860 (Print)
IS  - 1673-0860 (Linking)
VI  - 45
IP  - 6
DP  - 2010 Jun
TI  - [DJ-1 expression in laryngeal squamous cell carcinoma and its relationship with 
      tumor recurrence and metastasis].
PG  - 497-501
AB  - OBJECTIVE: To detect the expression of DJ-1 in laryngeal squamous cell carcinoma 
      (LSCC) and to study the relationship between DJ-1 expression and clinical indexes 
      of LSCC. METHODS: The expressions of DJ-1 protein in 71 LSCC samples and 9 cases 
      control samples from laryngeal mucosa tissues of non-LSCC patients were detected 
      using streptavidin peroxidase immunohistochemistry staining and the relationships 
      between DJ-1 protein expression and clinicopathologic characteristics were 
      analyzed. RESULTS: (1) The positive expression rate of DJ-1 protein in LSCC was 
      85.9%(61/71), which was significantly higher than the rate (55.5%, 5/9) in 
      control laryngeal mucosa tissues (P < 0.05). (2) DJ-1 expression was related to 
      tumor recurrence (P < 0.05), but not to sex, age, primary cancer position, T 
      stage, clinical stage, lymph node metastasis and tumor differentiation. Tumor 
      recurrence rate (53.3%) in the patients with higher expression of DJ-1 protein 
      was higher than the rate (26.8%) in the patients with lower expression of DJ-1 
      protein (chi(2) = 5.164, P < 0.05). (3) With Kaplan-Meier curves and Cox regression 
      analysis, the cumulative 5-year survival rates were correlated with DJ-1 
      expression levels in laryngeal cancer tissues or cervical lymph node metastasis 
      (all P < 0.05), but not to sex, age, primary cancer position, T stage, clinical 
      stage and tumor differentiation. CONCLUSIONS: The expression of DJ-1 protein in 
      LSCC is higher than that in control laryngeal mucous tissues. Overexpression of 
      DJ-1 is associated with poor overall survival in LSCC patients.
FAU - Zhu, Xiao-lin
AU  - Zhu XL
AD  - Otorhinolaryngology Hospital of First Affiliated Hospital of SUN Yat-sen 
      University, Otorhinolaryngology Institute of SUN Yat-sen University, Guangzhou 
      510080, China.
FAU - Wen, Wei-ping
AU  - Wen WP
FAU - Lei, Wen-bin
AU  - Lei WB
FAU - Chai, Li-ping
AU  - Chai LP
FAU - Hou, Wei-jian
AU  - Hou WJ
FAU - Wen, Yi-hui
AU  - Wen YH
FAU - Wang, Xian-ren
AU  - Wang XR
LA  - chi
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - China
TA  - Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi
JT  - Zhonghua er bi yan hou tou jing wai ke za zhi = Chinese journal of 
      otorhinolaryngology head and neck surgery
JID - 101247574
RN  - 0 (Intracellular Signaling Peptides and Proteins)
RN  - 0 (Oncogene Proteins)
RN  - EC 3.1.2.- (PARK7 protein, human)
RN  - EC 3.1.2.- (Protein Deglycase DJ-1)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Carcinoma, Squamous Cell/metabolism/*pathology
MH  - Case-Control Studies
MH  - Female
MH  - Humans
MH  - Intracellular Signaling Peptides and Proteins/*metabolism
MH  - Laryngeal Neoplasms/metabolism/*pathology
MH  - Lymphatic Metastasis
MH  - Male
MH  - Middle Aged
MH  - *Neoplasm Recurrence, Local
MH  - Neoplasm Staging
MH  - Oncogene Proteins/*metabolism
MH  - Protein Deglycase DJ-1
EDAT- 2010/11/09 06:00
MHDA- 2011/02/04 06:00
CRDT- 2010/11/09 06:00
PHST- 2010/11/09 06:00 [entrez]
PHST- 2010/11/09 06:00 [pubmed]
PHST- 2011/02/04 06:00 [medline]
PST - ppublish
SO  - Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi. 2010 Jun;45(6):497-501.