PMID- 21056522
OWN - NLM
STAT- MEDLINE
DCOM- 20110404
LR  - 20191210
IS  - 1873-6424 (Electronic)
IS  - 0269-7491 (Linking)
VI  - 159
IP  - 2
DP  - 2011 Feb
TI  - Nontarget analysis of polar contaminants in freshwater sediments influenced by 
      pharmaceutical industry using ultra-high-pressure liquid 
      chromatography-quadrupole time-of-flight mass spectrometry.
PG  - 557-66
LID - 10.1016/j.envpol.2010.10.009 [doi]
AB  - A comprehensive analytical procedure for a reliable identification of nontarget 
      polar contaminants in aquatic sediments was developed, based on the application 
      of ultra-high-pressure liquid chromatography (UHPLC) coupled to hybrid quadrupole 
      time-of-flight mass spectrometry (QTOFMS). The procedure was applied for the 
      analysis of freshwater sediment that was highly impacted by wastewater discharges 
      from the pharmaceutical industry. A number of different contaminants were 
      successfully identified owing to the high mass accuracy of the QTOFMS system, 
      used in combination with high chromatographic resolution of UHPLC. The major 
      compounds, identified in investigated sediment, included a series of 
      polypropylene glycols (n=3-16), alkylbenzene sulfonate and benzalkonium 
      surfactants as well as a number of various pharmaceuticals (chlorthalidone, 
      warfarin, terbinafine, torsemide, zolpidem and macrolide antibiotics). The 
      particular advantage of the applied technique is its capability to detect less 
      known pharmaceutical intermediates and/or transformation products, which have not 
      been previously reported in freshwater sediments.
CI  - Copyright (c) 2010 Elsevier Ltd. All rights reserved.
FAU - Terzic, Senka
AU  - Terzic S
AD  - Division of Marine and Environmental Research, Rudjer Boskovic Institute, 10000 
      Zagreb, Croatia. terzic@irb.hr
FAU - Ahel, Marijan
AU  - Ahel M
LA  - eng
PT  - Evaluation Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20101105
PL  - England
TA  - Environ Pollut
JT  - Environmental pollution (Barking, Essex : 1987)
JID - 8804476
RN  - 0 (Industrial Waste)
RN  - 0 (Pharmaceutical Preparations)
RN  - 0 (Water Pollutants, Chemical)
SB  - IM
MH  - Chromatography, High Pressure Liquid/*methods
MH  - Drug Industry
MH  - Fresh Water/analysis
MH  - Geologic Sediments/*analysis
MH  - Industrial Waste/*analysis
MH  - Mass Spectrometry/*methods
MH  - Pharmaceutical Preparations/*analysis
MH  - Water Pollutants, Chemical/*analysis
EDAT- 2010/11/09 06:00
MHDA- 2011/04/05 06:00
CRDT- 2010/11/09 06:00
PHST- 2010/08/02 00:00 [received]
PHST- 2010/10/07 00:00 [revised]
PHST- 2010/10/10 00:00 [accepted]
PHST- 2010/11/09 06:00 [entrez]
PHST- 2010/11/09 06:00 [pubmed]
PHST- 2011/04/05 06:00 [medline]
AID - S0269-7491(10)00465-3 [pii]
AID - 10.1016/j.envpol.2010.10.009 [doi]
PST - ppublish
SO  - Environ Pollut. 2011 Feb;159(2):557-66. doi: 10.1016/j.envpol.2010.10.009. Epub 
      2010 Nov 5.