PMID- 21056650
OWN - NLM
STAT- MEDLINE
DCOM- 20110526
LR  - 20111117
IS  - 1872-7573 (Electronic)
IS  - 0378-8741 (Linking)
VI  - 133
IP  - 2
DP  - 2011 Jan 27
TI  - Neuroprotective effect of Momordica charantia in global cerebral ischemia and 
      reperfusion induced neuronal damage in diabetic mice.
PG  - 729-34
LID - 10.1016/j.jep.2010.10.061 [doi]
AB  - ETHNOPHARMACOLOGICAL RELEVANCE: Momordica charantia L. (Cucurbitaceae) fruits 
      have been used traditionally for centuries, especially for treating diabetes and 
      associated complications. AIM OF THE STUDY: The present study was performed to 
      evaluate neuroprotective effect of lyophilized M. charantia fruit juice against 
      global cerebral ischemia and reperfusion induced neuronal injury in diabetic 
      mice. MATERIALS AND METHODS: Global cerebral ischemia induced by occluding both 
      common carotid arteries for 10 min followed by 24 h reperfusion was used to 
      induce neuronal injury. Ischemia-reperfusion induced neuronal injury was 
      evaluated in terms of cerebral infarct size, generation of free radicals measured 
      as thiobarbaturic acid reactive substances (TBARS), and neurological functions 
      measured as short term memory and motor activity. RESULTS: The cerebral oxidative 
      stress and damage, and neurological deficits were dose dependently attenuated by 
      pre-treatment with the lyophilized M. charantia juice (200-800 mg/kg, p.o., 
      o.d.). Moreover, M. charantia also exhibited dose dependent antihyperglycemic 
      activity in diabetic mice. CONCLUSIONS: These results suggest that M. charantia 
      has potent neuroprotective activity against global cerebral ischemia-reperfusion 
      induced neuronal injury and consequent neurological deficits in diabetic mice.
CI  - Copyright A(c) 2010 Elsevier Ireland Ltd. All rights reserved.
FAU - Malik, Zafar Ahmad
AU  - Malik ZA
AD  - Department of Pharmacology, ISF College of Pharmacy, Gal Kalan, Ferozpur Road, 
      Moga, Punjab 142001, India. zafar18@rediffmail.com
FAU - Singh, Manjeet
AU  - Singh M
FAU - Sharma, P L
AU  - Sharma PL
LA  - eng
PT  - Journal Article
DEP - 20101105
PL  - Ireland
TA  - J Ethnopharmacol
JT  - Journal of ethnopharmacology
JID - 7903310
RN  - 0 (Antioxidants)
RN  - 0 (Blood Glucose)
RN  - 0 (Insulin)
RN  - 0 (Neuroprotective Agents)
RN  - 0 (Thiobarbituric Acid Reactive Substances)
SB  - IM
MH  - Animals
MH  - Antioxidants/isolation & purification/pharmacology
MH  - Blood Glucose/metabolism
MH  - Brain Ischemia/complications/*drug therapy/physiopathology
MH  - Diabetes Mellitus, Experimental/complications/*drug therapy/physiopathology
MH  - Ethnopharmacology
MH  - Female
MH  - India
MH  - Insulin/pharmacology
MH  - Male
MH  - Medicine, Traditional
MH  - Memory, Short-Term/drug effects
MH  - Mice
MH  - *Momordica charantia/chemistry
MH  - Neuroprotective Agents/isolation & purification/*pharmacology
MH  - Phytotherapy
MH  - Plants, Medicinal/chemistry
MH  - Psychomotor Performance/drug effects
MH  - Reperfusion Injury/complications/drug therapy/physiopathology
MH  - Thiobarbituric Acid Reactive Substances/metabolism
EDAT- 2010/11/09 06:00
MHDA- 2011/05/27 06:00
CRDT- 2010/11/09 06:00
PHST- 2010/03/28 00:00 [received]
PHST- 2010/10/19 00:00 [revised]
PHST- 2010/10/31 00:00 [accepted]
PHST- 2010/11/09 06:00 [entrez]
PHST- 2010/11/09 06:00 [pubmed]
PHST- 2011/05/27 06:00 [medline]
AID - S0378-8741(10)00772-5 [pii]
AID - 10.1016/j.jep.2010.10.061 [doi]
PST - ppublish
SO  - J Ethnopharmacol. 2011 Jan 27;133(2):729-34. doi: 10.1016/j.jep.2010.10.061. Epub 
      2010 Nov 5.