PMID- 21057738
OWN - NLM
STAT- MEDLINE
DCOM- 20110218
LR  - 20120102
IS  - 1651-2057 (Electronic)
IS  - 0001-5555 (Linking)
VI  - 90
IP  - 6
DP  - 2010 Nov
TI  - Influence of the human leukocyte antigen complex on the development of cutaneous 
      fibrosis: an immunogenetic perspective.
PG  - 563-74
LID - 10.2340/00015555-0975 [doi]
AB  - A number of aesthetically and physically distressing disorders of the skin come 
      under the general term "cutaneous fibrosis", all sharing a common abnormal wound 
      healing process. These disorders are often incurable and effective treatments 
      remain to be established and, as such, they present a significant burden for 
      patients and a therapeutic challenge for clinicians. The aim of this review is to 
      investigate the evidence of either positive or negative associations of the human 
      leukocyte antigen (HLA) system with various types of cutaneous fibrosis, 
      focussing in particular on keloid scars, hypertrophic scars and scleroderma. A 
      standard systematic literature search was performed. The strengths and 
      limitations of studies were evaluated in terms of significance, methodology and 
      reproducibility. There is a clear association between specific HLA alleles and 
      predilection or protection to cutaneous fibrosis. Of these candidate HLA alleles, 
      the class II loci seem to be the most promising in terms of a genetic biomarker, 
      with the DQ and DR alleles having significant associations with abnormal wound 
      healing and cutaneous fibrosis. There is strong evidence of a significant immune 
      component in the pathogenesis of each type of fibrotic disorder explored in this 
      review. However, the exact mechanisms remain to be elucidated, since the 
      pathogenesis of cutaneous fibrosis and abnormal wound healing are not fully 
      understood.
FAU - McCarty, Sara M
AU  - McCarty SM
AD  - Manchester Interdisciplinary Biocentre, University of Manchester, United Kingdom.
FAU - Syed, Farhatullah
AU  - Syed F
FAU - Bayat, Ardeshir
AU  - Bayat A
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
PL  - Sweden
TA  - Acta Derm Venereol
JT  - Acta dermato-venereologica
JID - 0370310
RN  - 0 (HLA Antigens)
SB  - IM
MH  - Cicatrix, Hypertrophic/immunology/pathology
MH  - Connective Tissue Diseases/*immunology/pathology
MH  - Evidence-Based Medicine
MH  - Fibrosis
MH  - HLA Antigens/*immunology
MH  - Humans
MH  - Keloid/immunology/pathology
MH  - Scleroderma, Systemic/immunology/pathology
MH  - Skin/*immunology/pathology
MH  - Wound Healing
EDAT- 2010/11/09 06:00
MHDA- 2011/02/22 06:00
CRDT- 2010/11/09 06:00
PHST- 2010/11/09 06:00 [entrez]
PHST- 2010/11/09 06:00 [pubmed]
PHST- 2011/02/22 06:00 [medline]
AID - 10.2340/00015555-0975 [doi]
PST - ppublish
SO  - Acta Derm Venereol. 2010 Nov;90(6):563-74. doi: 10.2340/00015555-0975.