PMID- 21057903
OWN - NLM
STAT- MEDLINE
DCOM- 20110517
LR  - 20211020
IS  - 1546-9549 (Electronic)
IS  - 1546-9530 (Linking)
VI  - 8
IP  - 1
DP  - 2011 Mar
TI  - Intravenous iron in heart failure: beyond targeting anemia.
PG  - 14-21
LID - 10.1007/s11897-010-0034-4 [doi]
AB  - Iron deficiency is commonly seen in congestive heart failure (CHF) in both anemic 
      and nonanemic patients. In six studies in which these iron-deficient patients 
      with CHF were treated with intravenous (IV) iron, five found an improvement in 
      the hemoglobin. In uncontrolled and controlled studies, the New York Heart 
      Association (NYHA) class, quality of life, and exercise capacity were improved 
      consistently with IV iron. In some studies, cardiac function also was improved. 
      In one large, double-blind, placebo-controlled study of IV iron, the patient 
      global assessment, quality of life, and NYHA class improved rapidly in both those 
      who were anemic or not anemic. In contrast to these studies, another controlled 
      study of anemia in CHF showed no effect of oral iron on hemoglobin or on any 
      cardiac parameters over 1 year. These studies suggest that CHF in both anemic and 
      nonanemic iron-deficient patients may benefit from a course of IV iron, but not 
      oral iron.
FAU - Silverberg, Donald S
AU  - Silverberg DS
AD  - Department of Nephrology, Tel Aviv Sourasky Medical Center, Weizman 6, Tel Aviv, 
      Israel. donald@netvision.net.il
FAU - Iaina, Adrian
AU  - Iaina A
FAU - Schwartz, Doron
AU  - Schwartz D
FAU - Wexler, Dov
AU  - Wexler D
LA  - eng
PT  - Journal Article
PT  - Review
PL  - United States
TA  - Curr Heart Fail Rep
JT  - Current heart failure reports
JID - 101196487
RN  - 0 (Ferric Compounds)
RN  - 0 (Hematinics)
SB  - IM
MH  - Anemia, Iron-Deficiency/complications/*drug therapy
MH  - Ferric Compounds/*administration & dosage
MH  - Heart Failure/complications/*drug therapy
MH  - Hematinics/*administration & dosage
MH  - Humans
MH  - Injections, Intravenous
MH  - Renal Insufficiency, Chronic/complications
MH  - Treatment Outcome
EDAT- 2010/11/09 06:00
MHDA- 2011/05/18 06:00
CRDT- 2010/11/09 06:00
PHST- 2010/11/09 06:00 [entrez]
PHST- 2010/11/09 06:00 [pubmed]
PHST- 2011/05/18 06:00 [medline]
AID - 10.1007/s11897-010-0034-4 [doi]
PST - ppublish
SO  - Curr Heart Fail Rep. 2011 Mar;8(1):14-21. doi: 10.1007/s11897-010-0034-4.