PMID- 21059595
OWN - NLM
STAT- MEDLINE
DCOM- 20110812
LR  - 20220317
IS  - 1468-2079 (Electronic)
IS  - 0007-1161 (Linking)
VI  - 95
IP  - 7
DP  - 2011 Jul
TI  - HLA-DRB1*0102 is associated with TINU syndrome and bilateral, sudden-onset 
      anterior uveitis but not with interstitial nephritis alone.
PG  - 971-5
LID - 10.1136/bjo.2010.187955 [doi]
AB  - BACKGROUND: Tubulointerstitial nephritis and uveitis (TINU) syndrome is a rare 
      form of uveitis. Previously, the authors had demonstrated a strong association of 
      human leukocyte antigen (HLA) DRB1*0102 with TINU. Here, the authors performed 
      HLA analysis on subjects with isolated bilateral sudden-onset uveitis (as in the 
      TINU subtype) or with isolated tubulointerstitial nephritis (TIN). METHODS: 
      Patients with sudden onset, anterior, bilateral uveitis not fulfilling a 
      diagnosis of TINU were identified. Pathology reports were reviewed to identify 
      subjects with biopsy-proven TIN. Molecular typing of the HLA-DRB1 gene was 
      performed by the Luminex technology-based sequence-specific oligonucleotide (SSO) 
      hybridisation method (One Lambda, Canoga Park, California). HLA-DRB1 allele 
      frequencies were compared with normal published controls 
      (http://www.ncbi.nlm.nih.gov/projects/gv/mhc/ihwg.cgi dbMHC Europe cohort) and 
      the published TINU cohort (n=18). RESULTS: The authors included 28 subjects with 
      uveitis and 14 with TIN. There was a significantly higher frequency of DRB1*0102 
      in the isolated uveitis cohort versus in normal controls (10.7% vs 0.6%, 
      respectively, p<0.0001; RR 14.3 (6.9-29.8)). None of the nephritis patients 
      showed this HLA subtype. Another association with HLA-DRB1*08 was seen in the 
      isolated uveitis cohort with an allele frequency of 10.7% versus 2.7% in normal 
      controls (p=0.0019; RR 4.0 (1.8-9.0)). In contrast, the HLA-DRB1*08 was not 
      different from controls in the TINU cohort (allele frequency 2.8%, p=not 
      significant). CONCLUSION: The incidence of HLA-DRB1*0102 is increased in 
      sudden-onset bilateral anterior uveitis, as seen in patients with TINU. The same 
      allele does not appear to occur in increased frequency in patients with isolated 
      TIN. HLA DRB1*0102 might predispose to this subset of uveitis.
FAU - Mackensen, F
AU  - Mackensen F
AD  - Interdisciplinary Uveitis Center, University Eye Hospital, INF 400, 69120 
      Heidelberg, Germany. mackensen@uveitiszentrum.de
FAU - David, F
AU  - David F
FAU - Schwenger, V
AU  - Schwenger V
FAU - Smith, L K
AU  - Smith LK
FAU - Rajalingam, R
AU  - Rajalingam R
FAU - Levinson, R D
AU  - Levinson RD
FAU - Austin, C R
AU  - Austin CR
FAU - Houghton, D
AU  - Houghton D
FAU - Martin, T M
AU  - Martin TM
FAU - Rosenbaum, J T
AU  - Rosenbaum JT
LA  - eng
GR  - EY0105712/EY/NEI NIH HHS/United States
GR  - EY013139/EY/NEI NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
DEP - 20101107
PL  - England
TA  - Br J Ophthalmol
JT  - The British journal of ophthalmology
JID - 0421041
RN  - 0 (HLA-DR Antigens)
RN  - 0 (HLA-DRB1 Chains)
RN  - Tubulointerstitial nephritis and uveitis
SB  - IM
MH  - Acute Disease
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - Child
MH  - Female
MH  - Gene Frequency
MH  - Genetic Linkage
MH  - Genotype
MH  - HLA-DR Antigens/*genetics/metabolism
MH  - HLA-DRB1 Chains
MH  - Histocompatibility Testing
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Molecular Typing
MH  - Nephritis, Interstitial/genetics
MH  - Syndrome
MH  - Uveitis/genetics
MH  - Uveitis, Anterior/*genetics
MH  - Young Adult
EDAT- 2010/11/10 06:00
MHDA- 2011/08/13 06:00
CRDT- 2010/11/10 06:00
PHST- 2010/11/10 06:00 [entrez]
PHST- 2010/11/10 06:00 [pubmed]
PHST- 2011/08/13 06:00 [medline]
AID - bjo.2010.187955 [pii]
AID - 10.1136/bjo.2010.187955 [doi]
PST - ppublish
SO  - Br J Ophthalmol. 2011 Jul;95(7):971-5. doi: 10.1136/bjo.2010.187955. Epub 2010 
      Nov 7.