PMID- 21059899
OWN - NLM
STAT- MEDLINE
DCOM- 20110414
LR  - 20211020
IS  - 1528-0020 (Electronic)
IS  - 0006-4971 (Linking)
VI  - 117
IP  - 5
DP  - 2011 Feb 3
TI  - MHC variation and risk of childhood B-cell precursor acute lymphoblastic 
      leukemia.
PG  - 1633-40
LID - 10.1182/blood-2010-08-301598 [doi]
AB  - A role for specific human leukocyte antigen (HLA) variants in the etiology of 
      childhood acute lymphoblastic leukemia (ALL) has been extensively studied over 
      the last 30 years, but no unambiguous association has been identified. To 
      comprehensively study the relationship between genetic variation within the 4.5 
      Mb major histocompatibility complex genomic region and precursor B-cell (BCP) ALL 
      risk, we analyzed 1075 observed and 8176 imputed single nucleotide polymorphisms 
      and their related haplotypes in 824 BCP-ALL cases and 4737 controls. Using these 
      genotypes we also imputed both common and rare alleles at class I (HLA-A, HLA-B, 
      and HLA-C) and class II (HLA-DRB1, HLA-DQA1, and HLA-DQB1) HLA loci. Overall, we 
      found no statistically significant association between variants and BCP-ALL risk. 
      We conclude that major histocompatibility complex-defined variation in 
      immune-mediated response is unlikely to be a major risk factor for BCP-ALL.
FAU - Hosking, Fay J
AU  - Hosking FJ
AD  - Section of Cancer Genetics, Institute of Cancer Research, Sutton, Surrey, United 
      Kingdom.
FAU - Leslie, Stephen
AU  - Leslie S
FAU - Dilthey, Alexander
AU  - Dilthey A
FAU - Moutsianas, Loukas
AU  - Moutsianas L
FAU - Wang, Yufei
AU  - Wang Y
FAU - Dobbins, Sara E
AU  - Dobbins SE
FAU - Papaemmanuil, Elli
AU  - Papaemmanuil E
FAU - Sheridan, Eamonn
AU  - Sheridan E
FAU - Kinsey, Sally E
AU  - Kinsey SE
FAU - Lightfoot, Tracy
AU  - Lightfoot T
FAU - Roman, Eve
AU  - Roman E
FAU - Irving, Julie A E
AU  - Irving JA
FAU - Allan, James M
AU  - Allan JM
FAU - Taylor, Malcolm
AU  - Taylor M
FAU - Greaves, Mel
AU  - Greaves M
FAU - McVean, Gilean
AU  - McVean G
FAU - Houlston, Richard S
AU  - Houlston RS
LA  - eng
GR  - G0000934/MRC_/Medical Research Council/United Kingdom
GR  - C1298/A8362/CRUK_/Cancer Research UK/United Kingdom
GR  - 085475/WT_/Wellcome Trust/United Kingdom
GR  - 076113/WT_/Wellcome Trust/United Kingdom
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20101108
PL  - United States
TA  - Blood
JT  - Blood
JID - 7603509
RN  - 0 (Histocompatibility Antigens Class I)
RN  - 0 (Histocompatibility Antigens Class II)
SB  - IM
CIN - Blood. 2011 Feb 3;117(5):1441-2. PMID: 21292784
MH  - Alleles
MH  - Case-Control Studies
MH  - Child
MH  - Child, Preschool
MH  - Female
MH  - Genetic Predisposition to Disease
MH  - Genome-Wide Association Study
MH  - Genotype
MH  - Haplotypes/*genetics
MH  - Histocompatibility Antigens Class I/*genetics
MH  - Histocompatibility Antigens Class II/*genetics
MH  - Humans
MH  - Male
MH  - Polymorphism, Single Nucleotide/*genetics
MH  - Precursor B-Cell Lymphoblastic Leukemia-Lymphoma/*genetics/pathology
EDAT- 2010/11/10 06:00
MHDA- 2011/04/16 06:00
CRDT- 2010/11/10 06:00
PHST- 2010/11/10 06:00 [entrez]
PHST- 2010/11/10 06:00 [pubmed]
PHST- 2011/04/16 06:00 [medline]
AID - S0006-4971(20)60110-0 [pii]
AID - 10.1182/blood-2010-08-301598 [doi]
PST - ppublish
SO  - Blood. 2011 Feb 3;117(5):1633-40. doi: 10.1182/blood-2010-08-301598. Epub 2010 
      Nov 8.