PMID- 21060995
OWN - NLM
STAT- MEDLINE
DCOM- 20110714
LR  - 20211020
IS  - 1432-2072 (Electronic)
IS  - 0033-3158 (Linking)
VI  - 214
IP  - 3
DP  - 2011 Apr
TI  - Determining the subjective and physiological effects of BZP combined with TFMPP 
      in human males.
PG  - 761-8
LID - 10.1007/s00213-010-2081-7 [doi]
AB  - RATIONALE: 'Party Pills' containing benzylpiperazine (BZP) and 
      trifluoromethylphenylpiperazine (TFMPP) have been used in a recreational context 
      since the 1990s and, prior to April 2008, were legally available in New Zealand. 
      Taken together, they have been reported to produce a 'high' similar to that 
      produced by 3,4-methylenedioxymethamphetamine (MDMA). OBJECTIVES: There has been 
      little research on the subjective effects of piperazines in humans. The purpose 
      of this study is to further investigate the subjective and physiological 
      responses following an oral dose of BZP combined with TFMPP in males. METHODS: In 
      a randomised, double-blind, placebo-controlled study the subjective and 
      physiological effects of BZP/TFMPP were investigated in 36 healthy, non-smoking 
      males (mean age 22 +/- 4 years). Participants were tested before and approximately 
      120 min after administration of a single dose of placebo (n = 16) or 100/30 mg 
      BZP/TFMPP (n = 20). Participants were required to comment on the subjective 
      effects using three rating scales-the Addiction Research Centre Inventory (ARCI), 
      the Visual Analogue Scale (VAS) and the Profile of Mood States (POMS). 
      Participants' blood pressure, heart rate and body temperature were also measured. 
      RESULTS: Statistical analysis using repeated-measures analysis of variance 
      (ANOVA) and planned comparisons revealed that BZP/TFMPP significantly increases 
      blood pressure and heart rate (p < 0.05). Likewise, the subjective rating scales 
      revealed that BZP/TFMPP has significant dexamphetamine-like effects, increases 
      dysphoria and feelings of self-confidence (p < 0.05). CONCLUSION: These 
      physiological and subjective data reflect clear similarities between the effects 
      of BZP/TFMPP and commonly known stimulants such as dexamphetamine and MDMA.
FAU - Lin, Joanne C
AU  - Lin JC
AD  - School of Pharmacy, Faculty of Medical and Health Sciences, University of 
      Auckland, Private Bag, 92019 Auckland, New Zealand. joanne.lin@auckland.ac.nz
FAU - Jan, Reem K
AU  - Jan RK
FAU - Lee, HeeSeung
AU  - Lee H
FAU - Jensen, Maree-Ann
AU  - Jensen MA
FAU - Kydd, Rob R
AU  - Kydd RR
FAU - Russell, Bruce R
AU  - Russell BR
LA  - eng
PT  - Clinical Trial
PT  - Journal Article
PT  - Randomized Controlled Trial
PT  - Research Support, Non-U.S. Gov't
PL  - Germany
TA  - Psychopharmacology (Berl)
JT  - Psychopharmacology
JID - 7608025
RN  - 0 (Drug Combinations)
RN  - 0 (Illicit Drugs)
RN  - 0 (Piperazines)
RN  - 25R3ONU51C (1-(3-trifluoromethylphenyl)piperazine)
RN  - 3UG152ZU0E (1-benzylpiperazine)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Affect/*drug effects
MH  - Analysis of Variance
MH  - Blood Pressure/drug effects
MH  - Body Temperature/drug effects
MH  - Dose-Response Relationship, Drug
MH  - Double-Blind Method
MH  - Drug Combinations
MH  - Heart Rate/drug effects
MH  - Humans
MH  - Illicit Drugs/*pharmacology
MH  - Male
MH  - New Zealand
MH  - Pain Measurement
MH  - Physiological Phenomena/*drug effects
MH  - Piperazines/*pharmacology
MH  - Psychiatric Status Rating Scales
MH  - Young Adult
EDAT- 2010/11/10 06:00
MHDA- 2011/07/16 06:00
CRDT- 2010/11/10 06:00
PHST- 2010/09/13 00:00 [received]
PHST- 2010/10/27 00:00 [accepted]
PHST- 2010/11/10 06:00 [entrez]
PHST- 2010/11/10 06:00 [pubmed]
PHST- 2011/07/16 06:00 [medline]
AID - 10.1007/s00213-010-2081-7 [doi]
PST - ppublish
SO  - Psychopharmacology (Berl). 2011 Apr;214(3):761-8. doi: 10.1007/s00213-010-2081-7.