PMID- 21061539
OWN - NLM
STAT- MEDLINE
DCOM- 20110120
LR  - 20131121
IS  - 0047-1852 (Print)
IS  - 0047-1852 (Linking)
VI  - 68
IP  - 11
DP  - 2010 Nov
TI  - [Role of proton pump inhibitor in the management of low dose aspirin related 
      ulcerations].
PG  - 2096-101
AB  - Aspirin, as an anti-platelet medication, has been increasingly prescribed to 
      elderly patients for primary and secondary prevention of cardio--and 
      cerebro--vascular events. Nonetheless, aspirin's effectiveness in such disease 
      prevention is limited by the risk of gastrointestinal (GI) complications such as 
      ulceration, hemorrhage and perforation. Aspirin administration is associated with 
      2-fold increase in GI risk in middle-aged users without prior history of peptic 
      ulcer and without concomitant medications. However, the GI risk increases 
      dramatically in patients with a prior history of peptic ulcer disease, advanced 
      age, and concomitant use of NSAIDs, corticosteroids, clopidogrel, or 
      anticoagulants. Mechanisms of aspirin-induced GI injury are believed to be 
      through local effects within the GI mucosa that cause topical injury and through 
      systemic inhibition of cyclo-oxygenase (CO) resulting in depletion of mucosal 
      protective prostaglandins. Herein, we focus on the role of proton pump inhibitor 
      (PPI) in the strategy to prevent and to treat aspirin-induced peptic ulcerations 
      and their complications, based on the scientific evidence.
FAU - Hiraishi, Hideyuki
AU  - Hiraishi H
AD  - Department of Gastroenterology, Dokkyo Medical University.
FAU - Shimada, Tadahito
AU  - Shimada T
LA  - jpn
PT  - English Abstract
PT  - Journal Article
PT  - Review
PL  - Japan
TA  - Nihon Rinsho
JT  - Nihon rinsho. Japanese journal of clinical medicine
JID - 0420546
RN  - 0 (Anti-Inflammatory Agents, Non-Steroidal)
RN  - 0 (Proton Pump Inhibitors)
RN  - R16CO5Y76E (Aspirin)
SB  - IM
MH  - Aged
MH  - Anti-Inflammatory Agents, Non-Steroidal/*adverse effects
MH  - Aspirin/*adverse effects
MH  - Humans
MH  - Middle Aged
MH  - Peptic Ulcer/*chemically induced/*drug therapy/prevention & control
MH  - Proton Pump Inhibitors/*therapeutic use
EDAT- 2010/11/11 06:00
MHDA- 2011/01/21 06:00
CRDT- 2010/11/11 06:00
PHST- 2010/11/11 06:00 [entrez]
PHST- 2010/11/11 06:00 [pubmed]
PHST- 2011/01/21 06:00 [medline]
PST - ppublish
SO  - Nihon Rinsho. 2010 Nov;68(11):2096-101.