PMID- 21061540 OWN - NLM STAT- MEDLINE DCOM- 20110120 LR - 20110727 IS - 0047-1852 (Print) IS - 0047-1852 (Linking) VI - 68 IP - 11 DP - 2010 Nov TI - [Perforated peptic ulcer disease in the elderly]. PG - 2102-5 AB - There has been a marked decrease in elective surgery for peptic ulcer disease following introduction of medical therapies including H2-receptor antagonists (H2-RA) and proton pump inhibitors (PPI). By contrast, the incidence of emergency surgery for perforated peptic ulcer(PPU) has remained relatively unchanged, and potentially increased. Conservative treatment of PPU should be selected based on the physical condition of the patient. Open and laparoscopic repair of PPU are made with peritoneal lavage and omental patch closure of perforation. Laparoscopic repair of PPU seems better than open repair for low-risk patients. However, open repair for high-risk patients of PPU should not be delayed, and prognosis is affected primarily by concomitant medical comorbidity in the elderly. FAU - Kondoh, Yasumasa AU - Kondoh Y AD - Department of Surgery, Tokai University School of Medicine, Tokyo Hospital. LA - jpn PT - English Abstract PT - Journal Article PT - Review PL - Japan TA - Nihon Rinsho JT - Nihon rinsho. Japanese journal of clinical medicine JID - 0420546 SB - IM MH - Aged MH - Humans MH - Peptic Ulcer Perforation/surgery/*therapy EDAT- 2010/11/11 06:00 MHDA- 2011/01/21 06:00 CRDT- 2010/11/11 06:00 PHST- 2010/11/11 06:00 [entrez] PHST- 2010/11/11 06:00 [pubmed] PHST- 2011/01/21 06:00 [medline] PST - ppublish SO - Nihon Rinsho. 2010 Nov;68(11):2102-5.