PMID- 21062236
OWN - NLM
STAT- MEDLINE
DCOM- 20111018
LR  - 20221207
IS  - 1532-4311 (Electronic)
IS  - 0882-0139 (Linking)
VI  - 40
IP  - 2
DP  - 2011
TI  - Identification of HLA-DRB1 alleles associated with Graves' disease in Koreans by 
      sequence-based typing.
PG  - 172-82
LID - 10.3109/08820139.2010.525571 [doi]
AB  - The human leukocyte antigen (HLA) region, particularly class II genes, plays a 
      primary role in the susceptibility to development of GD. We investigated the 
      allelic polymorphism of HLA class II DRB1 genes to examine its association with 
      GD in Koreans. We performed the high resolution polymerase chain 
      reaction-sequence based typing (PCR-SBT) of HLA-DRB1 in 133 patients with GD and 
      200 healthy controls. Compared to healthy controls, the patients with GD had 
      increased frequencies of DRB1*030101 (4.9% vs.1.8%, p = 0.034), DRB1*080201 (5.3% 
      vs. 2.3%, p = 0.050) and DRB1*140301 (3.4% vs. 1.0%, p = 0.043). In contrast, the 
      frequencies of DRB1*070101 (3.0% vs. 7.3%, p = 0.024) and DRB1*130201 (4.1% vs. 
      9.0%, p = 0.010) were decreased in the patients with GD. However, the corrected p 
      values were not significant in above all alleles. Patients with DRB1*040301 were 
      significantly older than controls (45 years vs. 35 years, p = 0.017). 
      DRB1*040301, DRB1*150201, DRB1*120101 and DRB1*120201 were associated with male 
      predominance, strong familial associations, thyroid ophthalmopathy and 
      radioactive iodine therapy, respectively. In conclusion, there were no 
      significant HLA-DRB1 alleles associated with GD in Koreans, although some alleles 
      were correlated with the clinical characteristics.
FAU - Jang, Hye Won
AU  - Jang HW
AD  - Division of Endocrinology and Metabolism, Department of Medicine and Department 
      of Laboratory Medicine, Samsung Medical Center, Sungkyunkwan University School of 
      Medicine, Gangnam-Gu, Seoul, Korea.
FAU - Shin, Hyun Won
AU  - Shin HW
FAU - Cho, Hyun-Jung
AU  - Cho HJ
FAU - Kim, Hee Kyung
AU  - Kim HK
FAU - Lee, Ji In
AU  - Lee JI
FAU - Kim, Sun Wook
AU  - Kim SW
FAU - Kim, Jong-Won
AU  - Kim JW
FAU - Chung, Jae Hoon
AU  - Chung JH
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20101110
PL  - England
TA  - Immunol Invest
JT  - Immunological investigations
JID - 8504629
RN  - 0 (HLA-DR Antigens)
RN  - 0 (HLA-DRB1 Chains)
SB  - IM
MH  - Adult
MH  - Asian People/*genetics
MH  - Female
MH  - Gene Frequency/genetics
MH  - Genetic Association Studies
MH  - *Genetic Predisposition to Disease
MH  - Graves Disease/*genetics
MH  - HLA-DR Antigens/*genetics
MH  - HLA-DRB1 Chains
MH  - Histocompatibility Testing
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Polymerase Chain Reaction
MH  - Risk Factors
EDAT- 2010/11/11 06:00
MHDA- 2011/10/19 06:00
CRDT- 2010/11/11 06:00
PHST- 2010/11/11 06:00 [entrez]
PHST- 2010/11/11 06:00 [pubmed]
PHST- 2011/10/19 06:00 [medline]
AID - 10.3109/08820139.2010.525571 [doi]
PST - ppublish
SO  - Immunol Invest. 2011;40(2):172-82. doi: 10.3109/08820139.2010.525571. Epub 2010 
      Nov 10.