PMID- 21062488
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20110714
LR  - 20211020
IS  - 1472-6823 (Electronic)
IS  - 1472-6823 (Linking)
VI  - 10
DP  - 2010 Nov 9
TI  - Short term effects of a low-carbohydrate diet in overweight and obese subjects 
      with low HDL-C levels.
PG  - 18
LID - 10.1186/1472-6823-10-18 [doi]
AB  - BACKGROUND: The aim of this study was to evaluate short-term effects of a 
      low-carbohydrate diet in overweight and obese subjects with low HDL-C levels. 
      METHODS: Overweight (BMI between 25-30 kg/m2) or obese (BMI over 30 kg/m2) 
      subjects with low HDL-C levels (men with HDL-C <1.03, women <1.29 mmol/l) were 
      invited to the study. A 1400 kcal 75-gram carbohydrate (CHO) diet was given to 
      women and an 1800 kcal 100-gram CHO diet was given to men for four weeks. The 
      distribution of daily energy of the prescribed diet was 21-22% from CHO, 26-29% 
      from protein and 49-53% from fat. Subjects completed a three-day dietary intake 
      record before each visit. Anthropometric indices, body fat ratio, blood lipids, 
      glucose and insulin were measured. Baseline and week-four results were compared 
      with a Wilcoxon signed ranks test. RESULTS: Twenty-five women and 18 men 
      participated. Basal median LDL-C level of men was 3.11 and basal median LDL-C 
      level of women was 3.00 mmol/l. After four weeks of a low-carbohydrate diet, the 
      median energy intake decreased from 1901 to 1307 kcal/day, daily energy from 
      carbohydrate from 55% to 33%, body weight from 87.7 to 83.0 kg and HDL-C 
      increased from 0.83 to 0.96 mmol/l in men (p < 0.002, for all). After four weeks 
      of a low-carbohydrate diet, the median energy intake tended to decrease (from 
      1463 to 1243 kcal, p = 0.052), daily energy from carbohydrate decreased from 53% 
      to 30% (p < 0.001) and body weight decreased from 73.2 to 70.8 kg (p < 0.001) in 
      women, but HDL-C did not significantly change (from 1.03 to 1.01 mmol/l, p = 
      0.165). There were significant decreases in body mass index, waist circumference, 
      body fat ratio, systolic blood pressure, total cholesterol, triglyceride and 
      insulin levels in all subjects. CONCLUSIONS: HDL-C levels increased significantly 
      with energy restriction, carbohydrate restriction and weight loss in men. HDL-C 
      levels didn't change in women in whom there was no significant energy restriction 
      but a significant carbohydrate restriction and a relatively small but significant 
      weight loss. Our results suggest that both energy and carbohydrate restriction 
      should be considered in overweight and obese subjects with low HDL-C levels, 
      especially when LDL-C levels are not elevated.
FAU - Can, Ahmet Selcuk
AU  - Can AS
AD  - Department of Medicine, Kadir Has University, Faculty of Medicine, Vefa Bey 
      Sokak, No: 5, 34349, Gayrettepe, Besiktas, Istanbul, Turkey. 
      selcukcan@endokrinoloji.com.
FAU - Uysal, Canan
AU  - Uysal C
FAU - Palaoglu, K Erhan
AU  - Palaoglu KE
LA  - eng
PT  - Journal Article
DEP - 20101109
PL  - England
TA  - BMC Endocr Disord
JT  - BMC endocrine disorders
JID - 101088676
PMC - PMC2994852
EDAT- 2010/11/11 06:00
MHDA- 2010/11/11 06:01
PMCR- 2010/11/09
CRDT- 2010/11/11 06:00
PHST- 2010/04/08 00:00 [received]
PHST- 2010/11/09 00:00 [accepted]
PHST- 2010/11/11 06:00 [entrez]
PHST- 2010/11/11 06:00 [pubmed]
PHST- 2010/11/11 06:01 [medline]
PHST- 2010/11/09 00:00 [pmc-release]
AID - 1472-6823-10-18 [pii]
AID - 10.1186/1472-6823-10-18 [doi]
PST - epublish
SO  - BMC Endocr Disord. 2010 Nov 9;10:18. doi: 10.1186/1472-6823-10-18.