PMID- 21063237
OWN - NLM
STAT- MEDLINE
DCOM- 20110729
LR  - 20110421
IS  - 1473-5873 (Electronic)
IS  - 0955-8829 (Linking)
VI  - 21
IP  - 3
DP  - 2011 Jun
TI  - Effect of ADRA2A and BDNF gene-gene interaction on the continuous performance 
      test phenotype.
PG  - 132-5
LID - 10.1097/YPG.0b013e328341a389 [doi]
AB  - Complex phenotypes such as performance on the continuous performance test (CPT) 
      are likely to exhibit epistasis. Genetic polymorphisms of noradrenergic system 
      and brain-derived neurotrophic factor (BDNF), which participates in the 
      differentiation and survival of noradrenergic neurons, have been reported to be 
      associated with the performance on CPT. We evaluated the effect of the adrenergic 
      alpha-2A receptor (ADRA2A) and BDNF gene-gene interaction on performance on the CPT 
      in a Korean population with attention-deficit/hyperactivity disorder. In all, 122 
      participants with attention-deficit/hyperactivity disorder (8.6+/-2.3 years, 104 
      boys and 18 girls) completed the CPT. The DraI polymorphism of ADRA2A (rs583668) 
      and rs11030101 polymorphism of BDNF were genotyped. Significant interaction 
      effect was found of ADRA2A rs553668 and BDNF rs11030101 on response time 
      variability (P=0.011) of the CPT. Our study provides preliminary evidence for the 
      effect of the BDNF and ADRA2A gene-gene interaction on performance on the CPT in 
      attention-deficit/hyperactivity disorder.
FAU - Cho, Soo-Churl
AU  - Cho SC
AD  - Division of Child and Adolescent Psychiatry, Department of Neuropsychiatry, Seoul 
      National University College of Medicine, Korea.
FAU - Kim, Jae-Won
AU  - Kim JW
FAU - Kim, Hyo-Won
AU  - Kim HW
FAU - Kim, Boong-Nyun
AU  - Kim BN
FAU - Shin, Min-Sup
AU  - Shin MS
FAU - Cho, Dae-Yeon
AU  - Cho DY
FAU - Jung, Sun-Woo
AU  - Jung SW
FAU - Chung, Un-Sun
AU  - Chung US
FAU - Son, Jung-Woo
AU  - Son JW
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Psychiatr Genet
JT  - Psychiatric genetics
JID - 9106748
RN  - 0 (ADRA2A protein, human)
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (DNA Primers)
RN  - 0 (Receptors, Adrenergic, alpha-2)
SB  - IM
MH  - Attention Deficit Disorder with Hyperactivity/*genetics
MH  - Base Sequence
MH  - Brain-Derived Neurotrophic Factor/*genetics
MH  - Child
MH  - DNA Primers
MH  - *Epistasis, Genetic
MH  - Female
MH  - Humans
MH  - Male
MH  - Phenotype
MH  - Receptors, Adrenergic, alpha-2/*genetics
EDAT- 2010/11/11 06:00
MHDA- 2011/07/30 06:00
CRDT- 2010/11/11 06:00
PHST- 2010/11/11 06:00 [entrez]
PHST- 2010/11/11 06:00 [pubmed]
PHST- 2011/07/30 06:00 [medline]
AID - 10.1097/YPG.0b013e328341a389 [doi]
PST - ppublish
SO  - Psychiatr Genet. 2011 Jun;21(3):132-5. doi: 10.1097/YPG.0b013e328341a389.