PMID- 21063899
OWN - NLM
STAT- MEDLINE
DCOM- 20110418
LR  - 20211020
IS  - 1573-4919 (Electronic)
IS  - 0300-8177 (Linking)
VI  - 348
IP  - 1-2
DP  - 2011 Feb
TI  - Effect of lignin-derived lignophenols on vascular oxidative stress and 
      inflammation in streptozotocin-induced diabetic rats.
PG  - 117-24
LID - 10.1007/s11010-010-0645-9 [doi]
AB  - Lignophenols (LP) are the derivatives of native lignin, which is an abundant 
      organic polymer in the plant kingdom. This study investigated whether LP can 
      attenuate vascular oxidative stress and inflammation in streptozotocin 
      (STZ)-induced diabetic rats. The diabetic rats induced by a single intravenous 
      injection of STZ were randomly divided into two groups fed either 0 or 1.0% 
      LP-containing diet. After 5 weeks of treatment, the superoxide (O(2)(-)) 
      production, mRNA expression levels of nicotinamide adenine dinucleotide 
      (phosphate) (NAD(P)H) oxidase subunits, monocyte chemoattractant protein-1 
      (MCP-1) and its receptor C-C chemokine receptor 2 (CCR2), and protein expression 
      level of inducible nitric oxide synthase (iNOS) were examined in the aorta of 
      vehicle-injected control and diabetic rats treated with or without LP. The 
      increased O(2)(-) production and mRNA expression levels of NAD(P)H oxidase 
      subunits Nox4 and p47phox were found to be significantly reduced in the aorta of 
      diabetic rats treated with LP. The mRNA expression of MCP-1 and CCR2, and the 
      protein expression of iNOS were found to be increased in the aorta of untreated 
      diabetic rats, whereas these levels were significantly lower in the LP-treated 
      group. These findings suggest that LP could attenuate vascular oxidative stress 
      and/or inflammation via inhibition of NAD(P)H oxidase. This may lead to an 
      improvement in the vascular impairment of diabetes.
FAU - Mukai, Yuuka
AU  - Mukai Y
AD  - Department of Nutrition, Faculty of Health Sciences, Aomori University of Health 
      and Welfare, Hamadate, Aomori, Japan.
FAU - Norikura, Toshio
AU  - Norikura T
FAU - Fujita, Shuzo
AU  - Fujita S
FAU - Mikame, Keigo
AU  - Mikame K
FAU - Funaoka, Masamitsu
AU  - Funaoka M
FAU - Sato, Shin
AU  - Sato S
LA  - eng
PT  - Journal Article
DEP - 20101110
PL  - Netherlands
TA  - Mol Cell Biochem
JT  - Molecular and cellular biochemistry
JID - 0364456
RN  - 0 (Anti-Inflammatory Agents)
RN  - 0 (Antioxidants)
RN  - 0 (Blood Glucose)
RN  - 0 (Ccl2 protein, rat)
RN  - 0 (Ccr2 protein, rat)
RN  - 0 (Chemokine CCL2)
RN  - 0 (Lipids)
RN  - 0 (Phenols)
RN  - 0 (RNA, Messenger)
RN  - 0 (Receptors, CCR2)
RN  - 11062-77-4 (Superoxides)
RN  - 4Y8F71G49Q (Malondialdehyde)
RN  - 88847-89-6 (8-Hydroxy-2'-Deoxyguanosine)
RN  - 9005-53-2 (Lignin)
RN  - EC 1.14.13.39 (Nitric Oxide Synthase Type II)
RN  - EC 1.14.13.39 (Nos2 protein, rat)
RN  - EC 1.6.3.- (NADPH Oxidase 4)
RN  - EC 1.6.3.- (NADPH Oxidases)
RN  - EC 1.6.3.- (Nox4 protein, rat)
RN  - EC 1.6.3.1 (neutrophil cytosolic factor 1)
RN  - G9481N71RO (Deoxyguanosine)
SB  - IM
MH  - 8-Hydroxy-2'-Deoxyguanosine
MH  - Animals
MH  - Anti-Inflammatory Agents/*pharmacology
MH  - Antioxidants/*pharmacology
MH  - Aorta/*drug effects/immunology/metabolism
MH  - Blood Glucose/drug effects
MH  - Body Weight/drug effects
MH  - Chemokine CCL2/genetics/metabolism
MH  - Deoxyguanosine/analogs & derivatives/urine
MH  - Diabetes Mellitus, Experimental/*drug therapy/genetics/immunology/metabolism
MH  - *Fagus
MH  - Inflammation/genetics/immunology/metabolism/*prevention & control
MH  - Lignin/*pharmacology
MH  - Lipids/blood
MH  - Male
MH  - Malondialdehyde/blood
MH  - NADPH Oxidase 4
MH  - NADPH Oxidases/genetics/metabolism
MH  - Nitric Oxide Synthase Type II/genetics/metabolism
MH  - Oxidative Stress/*drug effects
MH  - Phenols/*pharmacology
MH  - RNA, Messenger/metabolism
MH  - Rats
MH  - Rats, Wistar
MH  - Receptors, CCR2/genetics/metabolism
MH  - Superoxides/metabolism
MH  - Time Factors
EDAT- 2010/11/11 06:00
MHDA- 2011/04/19 06:00
CRDT- 2010/11/11 06:00
PHST- 2010/08/20 00:00 [received]
PHST- 2010/10/28 00:00 [accepted]
PHST- 2010/11/11 06:00 [entrez]
PHST- 2010/11/11 06:00 [pubmed]
PHST- 2011/04/19 06:00 [medline]
AID - 10.1007/s11010-010-0645-9 [doi]
PST - ppublish
SO  - Mol Cell Biochem. 2011 Feb;348(1-2):117-24. doi: 10.1007/s11010-010-0645-9. Epub 
      2010 Nov 10.