PMID- 21064135
OWN - NLM
STAT- MEDLINE
DCOM- 20110211
LR  - 20101224
IS  - 1096-8652 (Electronic)
IS  - 0361-8609 (Linking)
VI  - 86
IP  - 1
DP  - 2011 Jan
TI  - Current status of pediatric umbilical cord blood transplantation in Korea: a 
      multicenter retrospective analysis of 236 cases.
PG  - 12-7
LID - 10.1002/ajh.21886 [doi]
AB  - We report the outcome of 236 pediatric umbilical cord blood transplantations 
      (UCBT) performed in Korea. Given that the sources of the grafts were mostly 
      unrelated donors (n = 226; 95.8%), only the results of unrelated UCBT were 
      included for all statistics. The most frequent primary disease was acute leukemia 
      (n = 167). In total, 91.7% of recipients were seropositive for cytomegalovirus 
      (CMV). The median doses of nucleated cells and CD34+ cells were 4.84 x 10(7)/kg 
      and 2.00 x 10(5)/kg, respectively. The median times to neutrophil (>0.5 x 
      10(9)/L) and platelet recovery (>20 x 10(9)/L) were 18 and 45 days, respectively. 
      Grade 2-4 acute graft-versus-host-disease (GVHD) and chronic GVHD developed in 
      41.1 and 36.1% of cases, respectively. Forty-five patients developed CMV disease. 
      The 5-year overall and event-free survival were 47.5 and 36.9%, respectively. 
      Multivariate analysis revealed that adverse factors for survival of the whole 
      cohort were total body irradiation-based conditioning (P = 0.007), salvage 
      transplant (P = 0.001), failure to achieve early complete chimerism (P < 0.0005), 
      and CMV disease (P = 0.001). The outcomes of the single- and double-unit UCBT (n 
      = 64) were similar, while double-unit recipients were heavier (P < 0.0005) and 
      older (P < 0.0005). We conclude that double-unit UCBT is a reasonable option for 
      older or heavier children and that the thorough surveillance of CMV infection and 
      the development of an effective CMV therapeutic strategy may be especially 
      important for Korean children, whose CMV seroprevalence exceeds 90%.
CI  - (c) 2010 Wiley-Liss, Inc.
FAU - Yoo, Keon Hee
AU  - Yoo KH
AD  - Department of Pediatrics, Samsung Medical Center, Sungkyunkwan University School 
      of Medicine, Seoul, Republic of Korea.
FAU - Lee, Soo Hyun
AU  - Lee SH
FAU - Sung, Ki Woong
AU  - Sung KW
FAU - Koo, Hong Hoe
AU  - Koo HH
FAU - Chung, Nak Gyun
AU  - Chung NG
FAU - Cho, Bin
AU  - Cho B
FAU - Kim, Hack Ki
AU  - Kim HK
FAU - Kang, Hyoung Jin
AU  - Kang HJ
FAU - Shin, Hee Young
AU  - Shin HY
FAU - Ahn, Hyo Seop
AU  - Ahn HS
FAU - Baek, Hee Jo
AU  - Baek HJ
FAU - Han, Dong Kyun
AU  - Han DK
FAU - Kook, Hoon
AU  - Kook H
FAU - Hwang, Tai Ju
AU  - Hwang TJ
FAU - Kim, Sun Young
AU  - Kim SY
FAU - Lee, Young Ho
AU  - Lee YH
FAU - Hah, Jeong Ok
AU  - Hah JO
FAU - Im, Ho Joon
AU  - Im HJ
FAU - Seo, Jong Jin
AU  - Seo JJ
FAU - Park, Sang Kyu
AU  - Park SK
FAU - Jung, Hyun Joo
AU  - Jung HJ
FAU - Park, Jun Eun
AU  - Park JE
FAU - Lim, Yeon Jung
AU  - Lim YJ
FAU - Park, Seong Shik
AU  - Park SS
FAU - Lim, Young Tak
AU  - Lim YT
FAU - Yoo, Eun Sun
AU  - Yoo ES
FAU - Ryu, Kyung Ha
AU  - Ryu KH
FAU - Park, Hyeon Jin
AU  - Park HJ
FAU - Park, Byung Kiu
AU  - Park BK
LA  - eng
PT  - Journal Article
PT  - Multicenter Study
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Am J Hematol
JT  - American journal of hematology
JID - 7610369
RN  - 0 (HLA Antigens)
SB  - IM
MH  - Acute Disease
MH  - Adolescent
MH  - Child
MH  - Child, Preschool
MH  - *Cord Blood Stem Cell Transplantation
MH  - Cytomegalovirus Infections/etiology
MH  - Disease-Free Survival
MH  - Female
MH  - Fetal Blood/*transplantation
MH  - Graft vs Host Disease/immunology
MH  - HLA Antigens/immunology
MH  - *Hematopoietic Stem Cell Transplantation
MH  - Humans
MH  - Infant
MH  - Infant, Newborn
MH  - Leukemia/surgery
MH  - Male
MH  - Multivariate Analysis
MH  - Republic of Korea
MH  - Retrospective Studies
MH  - Treatment Outcome
EDAT- 2010/11/11 06:00
MHDA- 2011/02/12 06:00
CRDT- 2010/11/11 06:00
PHST- 2010/11/11 06:00 [entrez]
PHST- 2010/11/11 06:00 [pubmed]
PHST- 2011/02/12 06:00 [medline]
AID - 10.1002/ajh.21886 [doi]
PST - ppublish
SO  - Am J Hematol. 2011 Jan;86(1):12-7. doi: 10.1002/ajh.21886.