PMID- 21068541
OWN - NLM
STAT- MEDLINE
DCOM- 20110321
LR  - 20211020
IS  - 1554-8635 (Electronic)
IS  - 1554-8627 (Print)
IS  - 1554-8627 (Linking)
VI  - 7
IP  - 1
DP  - 2011 Jan
TI  - DAMP-mediated autophagy contributes to drug resistance.
PG  - 112-4
AB  - Damage-associated molecular pattern molecules (DAMPs) are cellularly derived 
      molecules that can initiate and perpetuate immune responses following trauma, 
      ischemia and other types of tissue damage in the absence of pathogenic infection. 
      High mobility group box 1 (HMGB1) is a prototypical DAMP and is associated with 
      the hallmarks of cancer. Recently we found that HMGB1 release after chemotherapy 
      treatment is a critical regulator of autophagy and a potential drug target for 
      therapeutic interventions in leukemia. Overexpression of HMGB1 by gene 
      transfection rendered leukemia cells resistant to cell death; whereas depletion 
      or inhibition of HMGB1 and autophagy by RNA interference or pharmacological 
      inhibitors increased the sensitivity of leukemia cells to chemotherapeutic drugs. 
      HMGB1 release sustains autophagy as assessed by microtubule-associated protein 1 
      light chain 3 (LC3) lipidation, redistribution of LC3 into cytoplasmic puncta, 
      degradation of p62 and accumulation of autophagosomes and autolysosomes. 
      Moreover, these data suggest a role for HMGB1 in the regulation of autophagy 
      through the PI3KC3-MEKERK: pathway, supporting the notion that HMGB1-induced 
      autophagy promotes tumor resistance to chemotherapy.
FAU - Liu, Liying
AU  - Liu L
AD  - Department of Pediatrics, Xiangya Hospital, Central South University, Changsha, 
      China.
FAU - Yang, Minghua
AU  - Yang M
FAU - Kang, Rui
AU  - Kang R
FAU - Wang, Zhuo
AU  - Wang Z
FAU - Zhao, Yiming
AU  - Zhao Y
FAU - Yu, Yan
AU  - Yu Y
FAU - Xie, Min
AU  - Xie M
FAU - Yin, Xiaocheng
AU  - Yin X
FAU - Livesey, Kristen M
AU  - Livesey KM
FAU - Loze, Michael T
AU  - Loze MT
FAU - Tang, Daolin
AU  - Tang D
FAU - Cao, Lizhi
AU  - Cao L
LA  - eng
PT  - Journal Article
DEP - 20110101
PL  - United States
TA  - Autophagy
JT  - Autophagy
JID - 101265188
RN  - 0 (HMGB1 Protein)
RN  - 0 (Receptors, Pattern Recognition)
RN  - EC 2.7.1.- (Phosphatidylinositol 3-Kinases)
SB  - IM
MH  - *Autophagy
MH  - *Drug Resistance, Neoplasm
MH  - HMGB1 Protein/metabolism
MH  - Humans
MH  - Leukemia/enzymology/pathology
MH  - MAP Kinase Signaling System
MH  - Models, Biological
MH  - Phosphatidylinositol 3-Kinases/metabolism
MH  - Receptors, Pattern Recognition/*metabolism
PMC - PMC3039734
EDAT- 2010/11/12 06:00
MHDA- 2011/03/22 06:00
PMCR- 2011/01/01
CRDT- 2010/11/12 06:00
PHST- 2010/11/12 06:00 [entrez]
PHST- 2010/11/12 06:00 [pubmed]
PHST- 2011/03/22 06:00 [medline]
PHST- 2011/01/01 00:00 [pmc-release]
AID - 14005 [pii]
AID - 1554-8627-7-1-19 [pii]
AID - 10.4161/auto.7.1.14005 [doi]
PST - ppublish
SO  - Autophagy. 2011 Jan;7(1):112-4. doi: 10.4161/auto.7.1.14005. Epub 2011 Jan 1.