PMID- 21070839
OWN - NLM
STAT- MEDLINE
DCOM- 20111205
LR  - 20211020
IS  - 1873-7544 (Electronic)
IS  - 0306-4522 (Print)
IS  - 0306-4522 (Linking)
VI  - 172
DP  - 2011 Jan 13
TI  - A sex comparison of the anatomy and function of the main olfactory bulb-medial 
      amygdala projection in mice.
PG  - 196-204
LID - 10.1016/j.neuroscience.2010.11.003 [doi]
AB  - We previously reported that some main olfactory bulb (MOB) mitral/tufted (M/T) 
      cells send a direct projection to the "vomeronasal" amygdala in female mice and 
      selectively respond to volatile male mouse urinary odors. We asked whether MOB 
      M/T cells that project to the vomeronasal amygdala exist in male mice and whether 
      there is a sexually dimorphic response of these neurons to volatile male urinary 
      pheromones. Gonadectomized male and female mice received bilateral injections of 
      the retrograde tracer, Cholera toxin-B (CTb) into the medial amygdala (Me), which 
      is part of the vomeronasal amygdala. All subjects were then treated with 
      estradiol benzoate and progesterone before being exposed to volatile male urinary 
      odors whereupon they were sacrificed 90 min later. Sections of the MOB were 
      immunostained for Fos protein and/or CTb. Male mice, like females, displayed a 
      small population of MOB M/T cells that project to the Me. While the general 
      localization of these cells was similar in the two sexes, there were 
      statistically significant sex differences in the percentage of MOB M/T cells in 
      the anterior and posterior medial segments of the MOB that were retrogradely 
      labeled by CTb. Male urinary volatiles stimulated equivalent, significant 
      increases in Fos expression by MOB M/T neurons projecting to the Me in the two 
      sexes. By contrast, in the same mice exposure to male urinary volatiles 
      stimulated a significant increase in Fos expression by mitral cells in the 
      accessory olfactory bulb (AOB) only in female subjects. Thus any sexually 
      dimorphic behavioral or neuroendocrine responses to male urinary volatiles likely 
      depend on the differential processing of these odor inputs in the AOB and/or 
      other downstream forebrain structures after their detection by the main olfactory 
      system.
CI  - Copyright A(c) 2011 IBRO. Published by Elsevier Ltd. All rights reserved.
FAU - Kang, N
AU  - Kang N
AD  - Department of Biology, Boston University, Boston, MA 02215, USA.
FAU - McCarthy, E A
AU  - McCarthy EA
FAU - Cherry, J A
AU  - Cherry JA
FAU - Baum, M J
AU  - Baum MJ
LA  - eng
GR  - R01 DC008962/DC/NIDCD NIH HHS/United States
GR  - R01 DC008962-02/DC/NIDCD NIH HHS/United States
GR  - DC 008962/DC/NIDCD NIH HHS/United States
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
DEP - 20101109
PL  - United States
TA  - Neuroscience
JT  - Neuroscience
JID - 7605074
RN  - 0 (Neuronal Tract-Tracers)
RN  - 9012-63-9 (Cholera Toxin)
SB  - IM
MH  - Amygdala/cytology/*physiology
MH  - Animals
MH  - Brain Mapping/methods
MH  - Cholera Toxin/metabolism
MH  - Female
MH  - Immunohistochemistry
MH  - Male
MH  - Mice
MH  - Neuronal Tract-Tracers/metabolism
MH  - Olfactory Bulb/*cytology/*physiology
MH  - Olfactory Pathways/*cytology/*physiology
MH  - Sensory Receptor Cells/cytology/physiology
MH  - *Sex Characteristics
MH  - Smell/*physiology
PMC - PMC3010476
MID - NIHMS252049
EDAT- 2010/11/13 06:00
MHDA- 2011/12/13 00:00
PMCR- 2012/01/13
CRDT- 2010/11/13 06:00
PHST- 2010/09/27 00:00 [received]
PHST- 2010/10/21 00:00 [revised]
PHST- 2010/11/03 00:00 [accepted]
PHST- 2010/11/13 06:00 [entrez]
PHST- 2010/11/13 06:00 [pubmed]
PHST- 2011/12/13 00:00 [medline]
PHST- 2012/01/13 00:00 [pmc-release]
AID - S0306-4522(10)01469-7 [pii]
AID - 10.1016/j.neuroscience.2010.11.003 [doi]
PST - ppublish
SO  - Neuroscience. 2011 Jan 13;172:196-204. doi: 10.1016/j.neuroscience.2010.11.003. 
      Epub 2010 Nov 9.