PMID- 21071023
OWN - NLM
STAT- MEDLINE
DCOM- 20110422
LR  - 20110222
IS  - 1556-5653 (Electronic)
IS  - 0015-0282 (Linking)
VI  - 95
IP  - 3
DP  - 2011 Mar 1
TI  - Parental karyotype may reveal the source of a pregnancy loss even in the presence 
      of a reportedly euploid fetal karyotype.
PG  - 1120.e9-10
LID - 10.1016/j.fertnstert.2010.10.015 [doi]
AB  - OBJECTIVE: To present a case of a fetal loss in which a normal fetal karyotype 
      was obtained by banding studies. Identification of an abnormal maternal karyotype 
      prompted subsequent reanalysis using fluorescence in situ hybridization (FISH). 
      DESIGN: Case report. SETTING: University-affiliated IVF center. PATIENT(S): A 
      32-year-old woman, G1 P0, underwent a fetal loss at 8 weeks, and a suction 
      curettage was performed. The patient had a previous first-trimester loss. 
      INTERVENTION(S): The fetal tissue was evaluated by banding studies and found to 
      be normal. Parental karyotyping was performed, and the fetal tissue was 
      reanalyzed by FISH. MAIN OUTCOME MEASURE(S): Analysis of fetal karyotype by 
      targeted FISH. RESULT(S): Maternal karyotype demonstrated a translocation [46,XX, 
      t(8;10)(q24.3:q25.2)]. The fetal tissue was reanalyzed by FISH, and a segment of 
      chromosome 10 was found on chromosome 8. CONCLUSION(S): A normal fetal karyotype, 
      as measured by banding, does not exclude a genetic etiology for pregnancy loss. 
      In this case, maternal translocation prompted the genetics laboratory to search 
      for a small segment of translocated extra chromosomal material. This demonstrated 
      that despite the finding of a normal fetal karyotype, in some cases parental 
      karyotyping may have value.
CI  - Copyright (c) 2011 American Society for Reproductive Medicine. Published by 
      Elsevier Inc. All rights reserved.
FAU - Grunfeld, Lawrence
AU  - Grunfeld L
AD  - Department of Obstetrics and Gynecology, Mount Sinai Medical Center, New York, 
      New York 10022, USA. lgrunfeld@rmany.com
FAU - Sandler, Benjamin
AU  - Sandler B
FAU - Mukherjee, Tanmoy
AU  - Mukherjee T
FAU - Copperman, Alan B
AU  - Copperman AB
LA  - eng
PT  - Case Reports
PT  - Journal Article
DEP - 20101111
PL  - United States
TA  - Fertil Steril
JT  - Fertility and sterility
JID - 0372772
SB  - IM
MH  - Abortion, Habitual/*genetics
MH  - Adult
MH  - *Chromosome Aberrations
MH  - *Chromosomes, Human, Pair 10
MH  - *Chromosomes, Human, Pair 8
MH  - Female
MH  - Humans
MH  - In Situ Hybridization, Fluorescence
MH  - Parents
MH  - Pregnancy
MH  - *Translocation, Genetic
EDAT- 2010/11/13 06:00
MHDA- 2011/04/26 06:00
CRDT- 2010/11/13 06:00
PHST- 2010/07/23 00:00 [received]
PHST- 2010/09/17 00:00 [revised]
PHST- 2010/10/13 00:00 [accepted]
PHST- 2010/11/13 06:00 [entrez]
PHST- 2010/11/13 06:00 [pubmed]
PHST- 2011/04/26 06:00 [medline]
AID - S0015-0282(10)02691-9 [pii]
AID - 10.1016/j.fertnstert.2010.10.015 [doi]
PST - ppublish
SO  - Fertil Steril. 2011 Mar 1;95(3):1120.e9-10. doi: 
      10.1016/j.fertnstert.2010.10.015. Epub 2010 Nov 11.