PMID- 210711
OWN - NLM
STAT- MEDLINE
DCOM- 19781027
LR  - 20131121
IS  - 0003-5637 (Print)
IS  - 0003-5637 (Linking)
VI  - 23
IP  - 8
DP  - 1978 Aug
TI  - [Serum enzymatic activity in oncological patients treated with carminomycin].
PG  - 756-60
AB  - Karminomycin effect on the activity of some serum enzymes, such as hexokinase 
      (HK), lactate dehydrogenase (LDG), its isoenzymes and glucose-6-phosphatase 
      (G-6-P-ase) was studied. Biochemical assays were applied to 52 patients with 
      neglected malignant tumors. The course dose of the drug was on the average 72mg. 
      The objective antitumor effect was registered in 15 patients. A reliable increase 
      in the values of LDG-5 and G-6-P-ase was observed after the treatment course in 
      the combined group consisting of all the patients subjected to the biochemical 
      assay. Normalization of the serum enzyme spectrum was observed in 15 patients 
      effectively treated with karminomycin: activity of HK and the cathode fractions 
      of LDG decreased. When treatment with karminomycin was ineffective (37 cases), 
      the changes in the enzymatic activity recorded before the treatment further 
      aggraviated. It was found that the level of G-6-P-ase in the patients' treated 
      with karminomycin increased independent of the treatment effect which was 
      probably associated with its toxic effect on the liver. The increase was 
      reversible.
FAU - Gar'kavyi, M I
AU  - Gar'kavyi MI
FAU - Kovner, F Ia
AU  - Kovner FIa
LA  - rus
PT  - Clinical Trial
PT  - English Abstract
PT  - Journal Article
TT  - Aktivnost' nekotorykh fermentov syvorotki krovi u onkologicheskikh bol'nykh pri 
      lechenii karminomitsinom.
PL  - Russia (Federation)
TA  - Antibiotiki
JT  - Antibiotiki
JID - 0375020
RN  - 0 (Antibiotics, Antineoplastic)
RN  - 0 (Isoenzymes)
RN  - E7437K3983 (Carubicin)
RN  - EC 1.1.1.27 (L-Lactate Dehydrogenase)
RN  - EC 2.7.1.1 (Hexokinase)
RN  - EC 3.1.3.9 (Glucose-6-Phosphatase)
SB  - IM
MH  - Antibiotics, Antineoplastic/*therapeutic use
MH  - Blood/*drug effects
MH  - Carubicin/*therapeutic use
MH  - Clinical Trials as Topic
MH  - Enzyme Activation/drug effects
MH  - Female
MH  - Glucose-6-Phosphatase/blood
MH  - Hexokinase/blood
MH  - Humans
MH  - Isoenzymes
MH  - L-Lactate Dehydrogenase/blood
MH  - Neoplasms/drug therapy/*enzymology
EDAT- 1978/08/01 00:00
MHDA- 1978/08/01 00:01
CRDT- 1978/08/01 00:00
PHST- 1978/08/01 00:00 [pubmed]
PHST- 1978/08/01 00:01 [medline]
PHST- 1978/08/01 00:00 [entrez]
PST - ppublish
SO  - Antibiotiki. 1978 Aug;23(8):756-60.