PMID- 21071176
OWN - NLM
STAT- MEDLINE
DCOM- 20110307
LR  - 20221207
IS  - 1872-6844 (Electronic)
IS  - 0920-1211 (Linking)
VI  - 92
IP  - 2-3
DP  - 2010 Dec
TI  - Association study of lamotrigine-induced cutaneous adverse reactions and 
      HLA-B*1502 in a Han Chinese population.
PG  - 226-30
LID - 10.1016/j.eplepsyres.2010.10.006 [doi]
AB  - Antiepileptic drugs including lamotrigine (LTG) and carbamazepine (CBZ) are among 
      the most common causes of cutaneous adverse reactions (cADRs). Human leukocyte 
      antigen (HLA)-B*1502 has been strongly associated with CBZ-induced 
      Stevens-Johnson syndrome/toxic epidermal necrolysis (SJS/TEN). To investigate 
      this relationship, we performed high-resolution HLA genotyping on LTG-tolerant 
      controls, healthy volunteers, and patients affected by LTG-induced cADRs, ranging 
      from maculopapular exanthema (MPE) to SJS/TEN. Patients with LTG-induced cADRs 
      (n=25, including three with SJS/TEN and 22 with MPE), 21 LTG-tolerant controls, 
      and 71 healthy volunteers were enrolled. The differences in the starting dosage 
      of LTG among the SJS/TEN, MPE, and LTG-tolerant control groups were not 
      statistically significant. HLA-B*1502 frequency was 33.3% (1/3; LTG-induced 
      SJS/TEN group), 9.1% (2/22; LTG-induced MPE group), 4.8% (1/21; LTG-tolerant 
      group), and 8.5% (6/71; healthy volunteers). There was no significant difference 
      in the frequency of subjects with the HLA-B*1502 allele between the SJS/TEN group 
      and LTG-tolerant group (p=0.239, OR=10.0, 95% CI 0.44-228.7), and healthy 
      volunteers (p=0.26, OR=5.42, 95% CI 0.43-68.8), MPE and LTG-tolerant groups 
      (p=1.0, OR=1.08, 95% CI 0.20-5.8), and healthy volunteers (p=1.0, OR=2.0, 95% CI 
      0.17-23.9). None of the HLA alleles detected were associated with LTG-induced 
      cADRs. In conclusion, HLA-B*1502 and other HLA alleles are not directly 
      associated with LTG-induced MPE. The possibility that HLA-B*1502 is associated 
      with an increased risk of LTG-induced SJS/TEN could not be excluded.
CI  - Crown Copyright (c) 2010. Published by Elsevier B.V. All rights reserved.
FAU - An, Dong-Mei
AU  - An DM
AD  - Department of Neurology, West China Hospital, Sichuan University, Chengdu, 
      Sichuan Province 610041, China.
FAU - Wu, Xin-Tong
AU  - Wu XT
FAU - Hu, Fa-Yun
AU  - Hu FY
FAU - Yan, Bo
AU  - Yan B
FAU - Stefan, Hermann
AU  - Stefan H
FAU - Zhou, Dong
AU  - Zhou D
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20101110
PL  - Netherlands
TA  - Epilepsy Res
JT  - Epilepsy research
JID - 8703089
RN  - 0 (Anticonvulsants)
RN  - 0 (HLA-B Antigens)
RN  - 0 (Triazines)
RN  - U3H27498KS (Lamotrigine)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Anticonvulsants/*adverse effects
MH  - Asian People/ethnology
MH  - Epilepsy/drug therapy/genetics
MH  - Female
MH  - Gene Frequency
MH  - Genotype
MH  - HLA-B Antigens/*genetics
MH  - Humans
MH  - Lamotrigine
MH  - Male
MH  - Stevens-Johnson Syndrome/*chemically induced
MH  - Triazines/*adverse effects
MH  - Urticaria Pigmentosa/*chemically induced
MH  - Young Adult
EDAT- 2010/11/13 06:00
MHDA- 2011/03/08 06:00
CRDT- 2010/11/13 06:00
PHST- 2010/07/06 00:00 [received]
PHST- 2010/10/10 00:00 [revised]
PHST- 2010/10/11 00:00 [accepted]
PHST- 2010/11/13 06:00 [entrez]
PHST- 2010/11/13 06:00 [pubmed]
PHST- 2011/03/08 06:00 [medline]
AID - S0920-1211(10)00296-2 [pii]
AID - 10.1016/j.eplepsyres.2010.10.006 [doi]
PST - ppublish
SO  - Epilepsy Res. 2010 Dec;92(2-3):226-30. doi: 10.1016/j.eplepsyres.2010.10.006. 
      Epub 2010 Nov 10.