PMID- 21071552
OWN - NLM
STAT- MEDLINE
DCOM- 20120124
LR  - 20151119
IS  - 1477-0903 (Electronic)
IS  - 0960-3271 (Linking)
VI  - 30
IP  - 9
DP  - 2011 Sep
TI  - A traditional formula, Chunggan extract, attenuates thioacetamide-induced 
      hepatofibrosis via GSH system in rats.
PG  - 1322-32
LID - 10.1177/0960327110389502 [doi]
AB  - Chunggan extract (CGX) is a hepatotherapeutic herbal formula which has been 
      traditionally used for patients suffering from various hepatic disorders. This 
      study aimed to elucidate antifibrotic effect and mechanisms of CGX in 
      thioacetamide (TAA) model. Hepatic fibrosis was induced in 45 Sprague-Dawley rats 
      by TAA (200 mg kg(-1), intraperitoneally [ip]) on twice per week for 12 weeks. 
      CGX (100 or 200 mg kg(-1), per oral [po]) was administrated once a day throughout 
      the experiment. CGX treatment ameliorated serum biomarkers. CGX administration 
      significantly attenuated distortion of histopathologic finding, and accumulation 
      of hydroxyproline and malondialdehyde (MDA). CGX treatment significantly 
      decreased transforming growth factor-beta (TGF-beta) concentrations and inactivated 
      hepatic stellate cells (HSCs). CGX treatment drastically restored glutathione 
      (GSH) system, while inducible nitric oxide synthase (iNOS) and tumor necrosis 
      factor-alpha (TNF-alpha) significantly down-regulated in liver tissue. CGX showed 
      antifibrotic effect in thioacetamide-induced chronic liver injury model. Its 
      corresponding mechanisms may be mediated via anti-oxidative stress property 
      sustaining GSH system and inhibition of ROS production.
FAU - Kwak, Kyeong-Gue
AU  - Kwak KG
AD  - Liver and Immunology Research Center, Daejeon Oriental Hospital of Daejeon 
      University, Daejeon, Republic of Korea.
FAU - Wang, Jing-Hua
AU  - Wang JH
FAU - Shin, Jang-Woo
AU  - Shin JW
FAU - Lee, Dong-Soo
AU  - Lee DS
FAU - Son, Chang-Gue
AU  - Son CG
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20101111
PL  - England
TA  - Hum Exp Toxicol
JT  - Human & experimental toxicology
JID - 9004560
RN  - 0 (Biomarkers)
RN  - 0 (Drugs, Chinese Herbal)
RN  - 075T165X8M (Thioacetamide)
RN  - GAN16C9B8O (Glutathione)
SB  - IM
MH  - Animals
MH  - Biomarkers/blood
MH  - Drugs, Chinese Herbal/administration & dosage/*therapeutic use
MH  - Glutathione/*metabolism
MH  - Liver/*drug effects/enzymology/metabolism/pathology
MH  - Liver Cirrhosis, Experimental/chemically induced/metabolism/*prevention & control
MH  - Liver Function Tests
MH  - Male
MH  - Medicine, Korean Traditional
MH  - Oxidative Stress/drug effects
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - Thioacetamide/*pharmacology
EDAT- 2010/11/13 06:00
MHDA- 2012/01/25 06:00
CRDT- 2010/11/13 06:00
PHST- 2010/11/13 06:00 [entrez]
PHST- 2010/11/13 06:00 [pubmed]
PHST- 2012/01/25 06:00 [medline]
AID - 0960327110389502 [pii]
AID - 10.1177/0960327110389502 [doi]
PST - ppublish
SO  - Hum Exp Toxicol. 2011 Sep;30(9):1322-32. doi: 10.1177/0960327110389502. Epub 2010 
      Nov 11.