PMID- 21073328
OWN - NLM
STAT- MEDLINE
DCOM- 20110607
LR  - 20131121
IS  - 1563-5244 (Electronic)
IS  - 0883-0185 (Linking)
VI  - 29
IP  - 6
DP  - 2010 Dec
TI  - Novel findings in drug-induced dendritic cell tolerogenicity.
PG  - 574-607
LID - 10.3109/08830185.2010.522280 [doi]
AB  - Dendritic cells (DCs) constitute a unique set of antigen-presenting cells (APCs), 
      equipped with the potential to initiate strong immune responses as well as to 
      critically regulate immunity. Tolerogenic or "alternatively activated" DCs show 
      remarkable properties in regulating immune responses both in vitro and in vivo. 
      Furthermore, tolerogenic DCs are now beginning to be tested in clinical studies. 
      Use of pharmacological agents to induce maturation-resistant tolerogenic DCs is a 
      popular approach. In this review, we will discuss already recognized, as well as 
      recently discovered, potential pharmacological agents, their mechanism of action, 
      and the way in which they induce tolerance in DCs.
FAU - Svajger, Urban
AU  - Svajger U
AD  - Blood Transfusion Centre of Slovenia, Ljubljana, Slovenia, and Faculty of 
      Pharmacy, University of Ljubljana, Ljubljana, Slovenia. svajgerurban@yahoo.com
FAU - Obermajer, Natasa
AU  - Obermajer N
FAU - Jeras, Matjaz
AU  - Jeras M
LA  - eng
PT  - Journal Article
PT  - Review
PL  - England
TA  - Int Rev Immunol
JT  - International reviews of immunology
JID - 8712260
RN  - 0 (Histone Deacetylase Inhibitors)
RN  - 0 (Immunosuppressive Agents)
RN  - 0 (NF-kappa B)
RN  - 0 (PPAR gamma)
RN  - 0 (Purinergic P1 Receptor Agonists)
RN  - 0 (Receptors, Aryl Hydrocarbon)
RN  - E0399OZS9N (Cyclic AMP)
SB  - IM
MH  - Animals
MH  - Cell Differentiation/drug effects
MH  - Clinical Trials as Topic
MH  - Cyclic AMP/metabolism
MH  - Dendritic Cells/*drug effects/*immunology
MH  - *Drug Discovery/trends
MH  - Histone Deacetylase Inhibitors/pharmacology
MH  - Humans
MH  - *Immune Tolerance
MH  - Immunosuppressive Agents/pharmacology
MH  - NF-kappa B/*metabolism
MH  - PPAR gamma/metabolism
MH  - Purinergic P1 Receptor Agonists/pharmacology
MH  - Receptors, Aryl Hydrocarbon/agonists
MH  - Signal Transduction/drug effects/immunology
EDAT- 2010/11/16 06:00
MHDA- 2011/06/08 06:00
CRDT- 2010/11/16 06:00
PHST- 2010/11/16 06:00 [entrez]
PHST- 2010/11/16 06:00 [pubmed]
PHST- 2011/06/08 06:00 [medline]
AID - 10.3109/08830185.2010.522280 [doi]
PST - ppublish
SO  - Int Rev Immunol. 2010 Dec;29(6):574-607. doi: 10.3109/08830185.2010.522280.