PMID- 21073393
OWN - NLM
STAT- MEDLINE
DCOM- 20110610
LR  - 20171116
IS  - 1502-7686 (Electronic)
IS  - 0036-5513 (Linking)
VI  - 71
IP  - 1
DP  - 2011 Feb
TI  - Monocyte chemoattractant protein-1 is related to metabolic syndrome and 
      homocysteine in subjects without clinically significant atherosclerotic 
      cardiovascular disease.
PG  - 1-6
LID - 10.3109/00365513.2010.519047 [doi]
AB  - BACKGROUND: The features of the metabolic syndrome include glucose intolerance, 
      hypertension, dyslipidemia, and central obesity, all of which are risk factors 
      for diabetes and cardiovascular disease. Monocyte chemoattractant protein-1 
      (MCP-1) and interleukin-8 (IL-8) play a key role in atherosclerosis. We examined 
      the association between chemokines, such as MCP-1 and IL-8, and metabolic 
      syndrome. METHODS: The present study was comprised of 54 men and 126 women. 
      Subjects with cardiovascular disease such as myocardial infarction, TIA and 
      cerebral infarction were excluded. RESULTS: MCP-1 was positively correlated with 
      homeostasis model assessment of insulin resistance, homocysteine, and mean pulse 
      wave velocity, but IL-8 was not. In multiple regression analysis, age, HOMA-IR 
      and homocysteine were found to be an independent factor associated with MCP-1 
      adjusted by gender, waist, systolic blood pressure, triglyceride, 
      HDL-cholesterol, and hs-CRP. After adjustment for age and gender, mean MCP-1 was 
      higher in subjects with metabolic syndrome and in subject with high blood 
      pressure among the individual components of the metabolic syndrome. CONCLUSION: 
      MCP-1 was associated with a low-grade systemic inflammatory reaction which is 
      often found in the metabolic syndrome.
FAU - Kim, Sang-Hwan
AU  - Kim SH
AD  - Department of Family Medicine, Myongji Hospital, Kwandong University College of 
      Medicine, Goyang, Korea.
FAU - Lee, Ji-Won
AU  - Lee JW
FAU - Im, Jee-Aee
AU  - Im JA
FAU - Hwang, Hee-Jin
AU  - Hwang HJ
LA  - eng
PT  - Journal Article
DEP - 20101115
PL  - England
TA  - Scand J Clin Lab Invest
JT  - Scandinavian journal of clinical and laboratory investigation
JID - 0404375
RN  - 0 (CCL2 protein, human)
RN  - 0 (Chemokine CCL2)
RN  - 0 (Interleukin-8)
RN  - 0LVT1QZ0BA (Homocysteine)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Atherosclerosis/*blood/*complications
MH  - Chemokine CCL2/*blood
MH  - Female
MH  - Homocysteine/*blood
MH  - Humans
MH  - Interleukin-8/blood
MH  - Male
MH  - Metabolic Syndrome/*blood/*complications
MH  - Middle Aged
MH  - Multivariate Analysis
EDAT- 2010/11/16 06:00
MHDA- 2011/06/11 06:00
CRDT- 2010/11/16 06:00
PHST- 2010/11/16 06:00 [entrez]
PHST- 2010/11/16 06:00 [pubmed]
PHST- 2011/06/11 06:00 [medline]
AID - 10.3109/00365513.2010.519047 [doi]
PST - ppublish
SO  - Scand J Clin Lab Invest. 2011 Feb;71(1):1-6. doi: 10.3109/00365513.2010.519047. 
      Epub 2010 Nov 15.