PMID- 21073812
OWN - NLM
STAT- MEDLINE
DCOM- 20110524
LR  - 20220408
IS  - 1945-2403 (Electronic)
IS  - 0146-4760 (Linking)
VI  - 34
IP  - 9
DP  - 2010 Nov
TI  - Trazodone, meta-chlorophenylpiperazine (an hallucinogenic drug and trazodone 
      metabolite), and the hallucinogen trifluoromethylphenylpiperazine cross-react 
      with the EMIT(R)II ecstasy immunoassay in urine.
PG  - 587-9
AB  - A series of patients whose urine screened positive for 
      3,4-methylenedioxymethamphetamine (MDMA) using a commercial enzyme immunoassay 
      test (Ecstasy EMIT II assay), failed to confirm by substance-specific liquid 
      chromatography-tandem mass spectrometry tests for MDMA. Further evaluation of 
      these urine specimens indicates that they were positive for trazodone and its 
      metabolite meta-chlorophenylpiperazine (m-CPP). Independent tests of standards 
      showed significant crossreactivity on the Ecstasy EMIT II assay with trazodone, 
      m-CPP, and the related recreational drug trifluoromethylphenylpiperazine (TFMPP). 
      This is of further forensic significance because m-CPP is emerging as an illicit 
      recreational drug in its own right or as an adulterant in illicit cocaine and 
      MDMA. The hallucinogen benzylpiperazine was also assessed but found not to 
      cross-react significantly with this assay. Patients taking trazodone may get 
      false-positive results on the urine EMIT test for MDMA.
FAU - Logan, Barry K
AU  - Logan BK
AD  - NMS Labs, 3701 Welsh Rd., Willow Grove, Pennsylvania, USA.
FAU - Costantino, Anthony G
AU  - Costantino AG
FAU - Rieders, Eric F
AU  - Rieders EF
FAU - Sanders, David
AU  - Sanders D
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PL  - England
TA  - J Anal Toxicol
JT  - Journal of analytical toxicology
JID - 7705085
RN  - 0 (Antidepressive Agents)
RN  - 0 (Hallucinogens)
RN  - 0 (Illicit Drugs)
RN  - 0 (Piperazines)
RN  - 0 (Reagent Kits, Diagnostic)
RN  - 25R3ONU51C (1-(3-trifluoromethylphenyl)piperazine)
RN  - KE1SEN21RM (N-Methyl-3,4-methylenedioxyamphetamine)
RN  - REY0CNO998 (1-(3-chlorophenyl)piperazine)
RN  - YBK48BXK30 (Trazodone)
SB  - IM
MH  - Antidepressive Agents/pharmacokinetics/*urine
MH  - Cross Reactions
MH  - False Positive Reactions
MH  - Hallucinogens/*urine
MH  - Humans
MH  - Illicit Drugs/urine
MH  - Immunoassay
MH  - N-Methyl-3,4-methylenedioxyamphetamine/urine
MH  - Piperazines/*urine
MH  - Reagent Kits, Diagnostic
MH  - Substance Abuse Detection/*methods
MH  - Substance-Related Disorders/diagnosis
MH  - Trazodone/pharmacokinetics/*urine
EDAT- 2010/11/16 06:00
MHDA- 2011/05/25 06:00
CRDT- 2010/11/16 06:00
PHST- 2010/11/16 06:00 [entrez]
PHST- 2010/11/16 06:00 [pubmed]
PHST- 2011/05/25 06:00 [medline]
AID - 10.1093/jat/34.9.587 [doi]
PST - ppublish
SO  - J Anal Toxicol. 2010 Nov;34(9):587-9. doi: 10.1093/jat/34.9.587.