PMID- 21073842
OWN - NLM
STAT- MEDLINE
DCOM- 20110106
LR  - 20191111
IS  - 0722-5091 (Print)
IS  - 0722-5091 (Linking)
VI  - 29
IP  - 6
DP  - 2010 Nov-Dec
TI  - Cerebral low-grade lymphoma and light chain deposition disease: exceedingly high 
      IgG levels in the cerebrospinal fluid as a diagnostic clue.
PG  - 378-83
AB  - Herein, we report the case of a 72-year-old male with an exceedingly rare 
      manifestation of a low-grade lymphoma in the brain associated with light chain 
      deposition disease (LCDD). The patient presented with epileptic seizures. 
      Magnetic resonance imaging (MRI) of the brain revealed multiple hyperintense 
      lesions in the right parietal lobe that were suspicious of vasculitis, low-grade 
      glioma, or neurosarcoidosis. In the cerebrospinal fluid (CSF), but not in the 
      serum, highly elevated IgG was found. A stereotactic biopsy of one cerebral 
      lesion was performed. Histopathology revealed a low grade lymphoplasmacytic 
      B-cell lymphoma with light chain deposition disease (LCDD). Bone marrow biopsy 
      and laboratory workup did not show any systemic involvement. LCDD exclusively 
      affecting the brain is an exceedingly rare finding. It can be associated with 
      low-grade B-cell lymphoma. This is the first report of LCDD exclusively affecting 
      the brain in an elderly patient. Compared with the two younger patients 
      previously reported, the course of the disease was of a slow-evolving nature. In 
      constellations of highly elevated IgG in CSF and multiple white matter lesions, 
      LCDD should be considered as underlying pathology.
FAU - Pantazis, G
AU  - Pantazis G
AD  - Institute of Brain Research, University of Tuebingen, Germany. 
      georgios.pantazis@med.uni-tuebingen.de
FAU - Psaras, T
AU  - Psaras T
FAU - Krope, K
AU  - Krope K
FAU - von Coelln, R
AU  - von Coelln R
FAU - Fend, F
AU  - Fend F
FAU - Bock, T
AU  - Bock T
FAU - Schittenhelm, J
AU  - Schittenhelm J
FAU - Melms, A
AU  - Melms A
FAU - Meyermann, R
AU  - Meyermann R
FAU - Bornemann, A
AU  - Bornemann A
LA  - eng
PT  - Case Reports
PT  - Journal Article
PL  - Germany
TA  - Clin Neuropathol
JT  - Clinical neuropathology
JID - 8214420
RN  - 0 (Biomarkers)
RN  - 0 (Immunoglobulin G)
RN  - 0 (Immunoglobulin Light Chains)
SB  - IM
MH  - Aged
MH  - Biomarkers/cerebrospinal fluid
MH  - Biopsy
MH  - Bone Marrow/pathology
MH  - Brain Diseases/cerebrospinal fluid/*diagnosis/*immunology
MH  - Brain Neoplasms/cerebrospinal fluid/*diagnosis/pathology
MH  - Humans
MH  - Immunoglobulin G/*cerebrospinal fluid
MH  - Immunoglobulin Light Chains/*metabolism
MH  - Lymphoma, B-Cell/cerebrospinal fluid/*diagnosis/pathology
MH  - Lymphoma, Non-Hodgkin/cerebrospinal fluid/*diagnosis/pathology
MH  - Magnetic Resonance Imaging
MH  - Male
EDAT- 2010/11/16 06:00
MHDA- 2011/01/07 06:00
CRDT- 2010/11/16 06:00
PHST- 2010/11/16 06:00 [entrez]
PHST- 2010/11/16 06:00 [pubmed]
PHST- 2011/01/07 06:00 [medline]
AID - 8110 [pii]
AID - 10.5414/npp29378 [doi]
PST - ppublish
SO  - Clin Neuropathol. 2010 Nov-Dec;29(6):378-83. doi: 10.5414/npp29378.