PMID- 21074227
OWN - NLM
STAT- MEDLINE
DCOM- 20120827
LR  - 20111221
IS  - 1532-2661 (Electronic)
IS  - 0034-5288 (Linking)
VI  - 92
IP  - 1
DP  - 2012 Feb
TI  - Comparative study of the plasma globulin level, CD21(-) B-cell counts and FOXP3 
      mRNA expression level in CD4(+) T-cells for different clinical stages of feline 
      immunodeficiency virus infected cats.
PG  - 157-61
LID - 10.1016/j.rvsc.2010.10.022 [doi]
AB  - Feline immunodeficiency virus (FIV) infection leads to hypergammaglobulinemia 
      through mechanisms that remain poorly understood. We investigated changes in 
      plasma globulin level, B cells, and T cells with progression of the clinical 
      stage of FIV-infected cats. We classified FIV-infected cats into the stage of 
      Asymptomatic carrier (AC) and AIDS-related complex (ARC) based on the clinical 
      symptoms, and measured the plasma globulin level, the CD4(+) T-cell counts, and 
      analyzed surface markers of B cells. We investigated the relationship between the 
      plasma globulin level and regulatory T cells (Tregs) using the Forkhead box P3 
      (FOXP3) mRNA expression level. In FIV-infected cats, the plasma globulin level 
      and the surface immunoglobulin (sIg)(+) CD21(-) B-cell counts were increased, 
      whereas the CD4(+) T-cell counts were decreased compared with specific-pathogen 
      free (SPF) cats. The mRNA expression of Blimp-1 (master gene of plasma cells) was 
      increased in peripheral blood, and the FOXP3 mRNA expression level was decreased 
      in CD4(+) T-cells. These immunological changes were marked in the ARC stage. 
      These data indicate that the decrease of Tregs and the increase of plasma cells 
      lead to hypergammaglobulinemia.
CI  - Copyright (c) 2010 Elsevier Ltd. All rights reserved.
FAU - Takano, Tomomi
AU  - Takano T
AD  - Kitasato University, Towada, Aomori, Japan.
FAU - Hosoya, Shinobu
AU  - Hosoya S
FAU - Shibao, Akari
AU  - Shibao A
FAU - Nagasaki, Bunpei
AU  - Nagasaki B
FAU - Yoshioka, Hisao
AU  - Yoshioka H
FAU - Satoh, Ryoichi
AU  - Satoh R
FAU - Hohdatsu, Tsutomu
AU  - Hohdatsu T
LA  - eng
PT  - Comparative Study
PT  - Journal Article
DEP - 20101111
PL  - England
TA  - Res Vet Sci
JT  - Research in veterinary science
JID - 0401300
RN  - 0 (Forkhead Transcription Factors)
RN  - 0 (RNA, Messenger)
RN  - 0 (Receptors, Complement 3d)
RN  - 0 (Serum Globulins)
SB  - IM
MH  - Animals
MH  - B-Lymphocytes/*metabolism
MH  - CD4-Positive T-Lymphocytes/*metabolism
MH  - Case-Control Studies
MH  - Cat Diseases/*immunology/virology
MH  - Cats
MH  - Disease Progression
MH  - Feline Acquired Immunodeficiency Syndrome/immunology
MH  - Forkhead Transcription Factors/metabolism
MH  - Hypergammaglobulinemia/immunology/*veterinary/virology
MH  - *Immunodeficiency Virus, Feline/immunology
MH  - Lentivirus Infections/immunology/*veterinary
MH  - Lymphocyte Count/veterinary
MH  - RNA, Messenger/analysis
MH  - Receptors, Complement 3d/metabolism
MH  - Serum Globulins/*metabolism
MH  - T-Lymphocytes, Regulatory/metabolism
EDAT- 2010/11/16 06:00
MHDA- 2012/08/28 06:00
CRDT- 2010/11/16 06:00
PHST- 2010/08/16 00:00 [received]
PHST- 2010/10/15 00:00 [revised]
PHST- 2010/10/20 00:00 [accepted]
PHST- 2010/11/16 06:00 [entrez]
PHST- 2010/11/16 06:00 [pubmed]
PHST- 2012/08/28 06:00 [medline]
AID - S0034-5288(10)00374-7 [pii]
AID - 10.1016/j.rvsc.2010.10.022 [doi]
PST - ppublish
SO  - Res Vet Sci. 2012 Feb;92(1):157-61. doi: 10.1016/j.rvsc.2010.10.022. Epub 2010 
      Nov 11.