PMID- 21074286
OWN - NLM
STAT- MEDLINE
DCOM- 20110505
LR  - 20220311
IS  - 1872-8227 (Electronic)
IS  - 0168-8227 (Linking)
VI  - 91
IP  - 1
DP  - 2011 Jan
TI  - Use of the UKPDS Outcomes Model to predict all-cause mortality in U.S. adults 
      with type 2 diabetes mellitus: comparison of predicted versus observed mortality.
PG  - 121-6
LID - 10.1016/j.diabres.2010.10.011 [doi]
AB  - AIMS: The applicability of the United Kingdom Prospective Diabetes Study (UKPDS) 
      Outcomes Model is unknown in populations with type 2 diabetes mellitus (T2DM) 
      outside the United Kingdom. We compared all-cause mortality predicted from the 
      UKPDS model with observed mortality among T2DM subjects in the U.S. METHODS: we 
      studied participants with T2DM from the National Health and Nutrition Examination 
      Survey 1988-1994 with characteristics comparable to the UKPDS cohort. The 10-year 
      observed all-cause mortality was compared to the UKPDS model-predicted mortality. 
      The Lifetable method was used to estimate the probability of mortality for 10 
      years following diagnosis. RESULTS: among 156 subjects with characteristics 
      comparable to the UKPDS cohort, mean age was 49.6 years, age at T2DM diagnosis 
      was 47.1 years, and T2DM duration averaged 2.6 years, with follow-up for 10.4 
      years. The UKPDS model-predicted 10-year mortality was 15.7%, similar to the 
      observed mortality of 14.2%. Corresponding 10-year predicted versus observed 
      mortality was 32.7% versus 32.4% including subjects >age 65, 17.0% versus 19.3% 
      including individuals with pre-existing CVD, and 31.1% versus 20.9% including 
      individuals with diabetes duration >/= 6 years. CONCLUSION: all-cause mortality 
      predicted by the UKPDS model was comparable to observed mortality in U.S. NHANES 
      participants with characteristics similar to the UKPDS.
CI  - 2010 Elsevier Ireland Ltd. All rights reserved.
FAU - Song, May
AU  - Song M
AD  - Heart Disease Prevention Program, Division of Cardiology, Department of Medicine, 
      University of California, Irvine, CA, USA.
FAU - Alexander, Charles M
AU  - Alexander CM
FAU - Mavros, Panagiotis
AU  - Mavros P
FAU - Lopez, Victor A
AU  - Lopez VA
FAU - Malik, Shaista
AU  - Malik S
FAU - Phatak, Hemant M
AU  - Phatak HM
FAU - Wong, Nathan D
AU  - Wong ND
LA  - eng
PT  - Comparative Study
PT  - Evaluation Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20101111
PL  - Ireland
TA  - Diabetes Res Clin Pract
JT  - Diabetes research and clinical practice
JID - 8508335
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Cardiovascular Diseases/complications/mortality
MH  - Cohort Studies
MH  - Computer Simulation
MH  - Diabetes Complications/*mortality
MH  - Diabetes Mellitus, Type 2/*mortality
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Models, Statistical
MH  - *Mortality
MH  - Nutrition Surveys
MH  - Treatment Outcome
MH  - United Kingdom
MH  - United States
MH  - Young Adult
EDAT- 2010/11/16 06:00
MHDA- 2011/05/06 06:00
CRDT- 2010/11/16 06:00
PHST- 2010/05/07 00:00 [received]
PHST- 2010/09/30 00:00 [revised]
PHST- 2010/10/11 00:00 [accepted]
PHST- 2010/11/16 06:00 [entrez]
PHST- 2010/11/16 06:00 [pubmed]
PHST- 2011/05/06 06:00 [medline]
AID - S0168-8227(10)00522-X [pii]
AID - 10.1016/j.diabres.2010.10.011 [doi]
PST - ppublish
SO  - Diabetes Res Clin Pract. 2011 Jan;91(1):121-6. doi: 
      10.1016/j.diabres.2010.10.011. Epub 2010 Nov 11.