PMID- 21075156
OWN - NLM
STAT- MEDLINE
DCOM- 20110629
LR  - 20110117
IS  - 1879-1166 (Electronic)
IS  - 0198-8859 (Linking)
VI  - 72
IP  - 2
DP  - 2011 Feb
TI  - High frequency of low-risk human leukocyte antigen class II genotypes in latent 
      celiac disease.
PG  - 179-82
LID - 10.1016/j.humimm.2010.11.007 [doi]
AB  - Human leukocyte antigen (HLA) class II genotypes in latent celiac disease, a 
      clinical variant of celiac disease (CD) have been scarcely studied. The aim of 
      this work was to investigate whether latent CD and CD share similar frequencies 
      of HLA class II genotypes. HLA class II genotypes of CD patients compared with 
      controls were subdivided in the following at-risk groups: DQB1*02/DQB1*02 (43.0%, 
      odds ratio [OR] 8.02, p < 0.0001), DQB1*0302/DQB1*02 (12.2%, OR 2.77, p = 
      0.0002), DQB1*02/DQB1*X (39.2%, OR 1.23, p = 0.1903), DQB1*0302/DQB1*X (3.4%, OR 
      0.35, p = 0.0064) and DQB1*X/DQB1*X (0.8%, OR 0.01, p = 0.0001) where X is 
      neither DQB1*0302 nor DQB1*02. Next, HLA class II genotypes of 21 latent CD 
      patients were compared with the above at-risk groups. Only one latent CD patient 
      (4.8%) was found in the high risk DQB1*02/DQB1*02 group, three (14.3%) were 
      DQB1*0302/DQB1*02, one (4.8%) was DQB1*0302/DQB1*X and the remaining 16 (76.2%) 
      showed the DQB1*02/DQB1*X genotype. Noteworthy, the only 1 patient with the 
      DQB1*02/DQB1*02 high risk genotype did not carry the DR3-DQB1*02/DR3-DQB1*02 or 
      the DR3-DQB1*02/DR7-DQB1*02 but the uncommon DR3-DQB1*02/DR4-DQB1*02 genotype. 
      These data suggest that latent CD is prevalently associated with low-risk HLA 
      class II genotypes.
CI  - Copyright A(c) 2011 American Society for Histocompatibility and Immunogenetics. 
      Published by Elsevier Inc. All rights reserved.
FAU - Schirru, Enrico
AU  - Schirru E
AD  - Department of Pediatric Science and Clinical Medicine, University of Cagliari, 
      Cagliari, Italy.
FAU - Jores, Rita-Desiree
AU  - Jores RD
FAU - Cicotto, Lucia
AU  - Cicotto L
FAU - Frau, Fulvia
AU  - Frau F
FAU - De Virgiliis, Stefano
AU  - De Virgiliis S
FAU - Rossino, Rossano
AU  - Rossino R
FAU - Macis, Maria Doloretta
AU  - Macis MD
FAU - Lampis, Rosanna
AU  - Lampis R
FAU - Congia, Mauro
AU  - Congia M
LA  - eng
PT  - Journal Article
DEP - 20101112
PL  - United States
TA  - Hum Immunol
JT  - Human immunology
JID - 8010936
RN  - 0 (HLA-DQ Antigens)
SB  - IM
MH  - Alleles
MH  - Celiac Disease/genetics/*immunology
MH  - Child
MH  - Female
MH  - *Gene Frequency
MH  - Genetic Association Studies/statistics & numerical data
MH  - Genetic Predisposition to Disease/epidemiology
MH  - Genotype
MH  - HLA-DQ Antigens/genetics/*immunology
MH  - Haplotypes/*immunology
MH  - Humans
MH  - Male
MH  - Odds Ratio
MH  - Prevalence
MH  - Risk
MH  - Severity of Illness Index
EDAT- 2010/11/16 06:00
MHDA- 2011/06/30 06:00
CRDT- 2010/11/16 06:00
PHST- 2010/06/10 00:00 [received]
PHST- 2010/11/02 00:00 [revised]
PHST- 2010/11/08 00:00 [accepted]
PHST- 2010/11/16 06:00 [entrez]
PHST- 2010/11/16 06:00 [pubmed]
PHST- 2011/06/30 06:00 [medline]
AID - S0198-8859(10)00552-5 [pii]
AID - 10.1016/j.humimm.2010.11.007 [doi]
PST - ppublish
SO  - Hum Immunol. 2011 Feb;72(2):179-82. doi: 10.1016/j.humimm.2010.11.007. Epub 2010 
      Nov 12.