PMID- 21076561
OWN - NLM
STAT- MEDLINE
DCOM- 20110307
LR  - 20211020
IS  - 1564-0604 (Electronic)
IS  - 0042-9686 (Print)
IS  - 0042-9686 (Linking)
VI  - 88
IP  - 11
DP  - 2010 Nov 1
TI  - Intermittent preventive treatment for malaria in infants: a decision-support tool 
      for sub-Saharan Africa.
PG  - 807-14
LID - 10.2471/BLT.09.072397 [doi]
AB  - OBJECTIVE: To develop a decision-support tool to help policy-makers in 
      sub-Saharan Africa assess whether intermittent preventive treatment in infants 
      (IPTi) would be effective for local malaria control. METHODS: An algorithm for 
      predicting the effect of IPTi was developed using two approaches. First, study 
      data on the age patterns of clinical cases of Plasmodium falciparum malaria, 
      hospital admissions for infection with malaria parasites and malaria-associated 
      death for different levels of malaria transmission intensity and seasonality were 
      used to estimate the percentage of cases of these outcomes that would occur in 
      children aged <10 years targeted by IPTi. Second, a previously developed 
      stochastic mathematical model of IPTi was used to predict the number of cases 
      likely to be averted by implementing IPTi under different epidemiological 
      conditions. The decision-support tool uses the data from these two approaches 
      that are most relevant to the context specified by the user. FINDINGS: Findings 
      from the two approaches indicated that the percentage of cases targeted by IPTi 
      increases with the severity of the malaria outcome and with transmission 
      intensity. The decision-support tool, available on the Internet, provides 
      estimates of the percentage of malaria-associated deaths, hospitalizations and 
      clinical cases that will be targeted by IPTi in a specified context and of the 
      number of these outcomes that could be averted. CONCLUSION: The effectiveness of 
      IPTi varies with malaria transmission intensity and seasonality. Deciding where 
      to implement IPTi must take into account the local epidemiology of malaria. The 
      Internet-based decision-support tool described here predicts the likely 
      effectiveness of IPTi under a wide range of epidemiological conditions.
FAU - Carneiro, Ilona
AU  - Carneiro I
AD  - Faculty of Infectious and Tropical Diseases, London School of Hygiene and 
      Tropical Medicine, Keppel Street, London WC1E 7HT, England. 
      ilona.carneiro@lshtm.ac.uk
FAU - Smith, Lucy
AU  - Smith L
FAU - Ross, Amanda
AU  - Ross A
FAU - Roca-Feltrer, Arantxa
AU  - Roca-Feltrer A
FAU - Greenwood, Brian
AU  - Greenwood B
FAU - Schellenberg, Joanna Armstrong
AU  - Schellenberg JA
FAU - Smith, Thomas
AU  - Smith T
FAU - Schellenberg, David
AU  - Schellenberg D
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20100510
PL  - Switzerland
TA  - Bull World Health Organ
JT  - Bulletin of the World Health Organization
JID - 7507052
RN  - 0 (Antimalarials)
SB  - IM
MH  - Africa South of the Sahara/epidemiology
MH  - Age Distribution
MH  - Algorithms
MH  - Antimalarials/administration & dosage/*therapeutic use
MH  - Child
MH  - Child, Preschool
MH  - Confidence Intervals
MH  - *Decision Support Techniques
MH  - Epidemiologic Methods
MH  - Female
MH  - *Health Policy
MH  - Hospitalization
MH  - Humans
MH  - Infant
MH  - Infant, Newborn
MH  - Malaria/epidemiology/mortality/*prevention & control
MH  - Male
MH  - Models, Theoretical
MH  - Plasmodium malariae/*isolation & purification
MH  - Stochastic Processes
MH  - Time Factors
PMC - PMC2971505
EDAT- 2010/11/16 06:00
MHDA- 2011/03/08 06:00
PMCR- 2010/11/01
CRDT- 2010/11/16 06:00
PHST- 2009/09/28 00:00 [received]
PHST- 2010/03/05 00:00 [revised]
PHST- 2010/03/10 00:00 [accepted]
PHST- 2010/11/16 06:00 [entrez]
PHST- 2010/11/16 06:00 [pubmed]
PHST- 2011/03/08 06:00 [medline]
PHST- 2010/11/01 00:00 [pmc-release]
AID - BLT.09.072397 [pii]
AID - 10.2471/BLT.09.072397 [doi]
PST - ppublish
SO  - Bull World Health Organ. 2010 Nov 1;88(11):807-14. doi: 10.2471/BLT.09.072397. 
      Epub 2010 May 10.