PMID- 21076580
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20110714
LR  - 20211020
IS  - 2093-2650 (Electronic)
IS  - 1976-9180 (Print)
IS  - 1976-9180 (Linking)
VI  - 34
IP  - 5
DP  - 2010 Oct
TI  - ENPP1 K121Q Genotype Not Associated with Coronary Artery Calcification in Korean 
      Patients with Type 2 Diabetes Mellitus.
PG  - 320-6
LID - 10.4093/kdj.2010.34.5.320 [doi]
AB  - BACKGROUND: Ectonucleotide pyrophosphatase/phosphodiesterase-1 (ENPP1) generates 
      inorganic pyrophosphate, a solute that serves as an essential physiological 
      inhibitor of calcification. Inactivating mutations of ENPP1 are associated with 
      generalized calcification in infancy and an increased risk of developing type 2 
      diabetes mellitus (T2DM). We hypothesized that the ENPP1 K121Q variant may be 
      associated with increased coronary artery calcification in T2DM patients. 
      METHODS: The study subjects were aged 34 to 85 years and showed no evidence of 
      clinical cardiovascular disease prior to recruitment. A total of 140 patients 
      with T2DM were assessed for their coronary artery calcium (CAC) scores and ENPP1 
      K121Q polymorphisms were identified. RESULTS: The prevalence of subjects carrying 
      the KQ genotype was 12.9% (n = 18). There were no 121QQ homozygotes. Patients 
      with the KQ genotype did not show a significantly higher CAC score (122 vs. 18; P 
      = 0.858). We matched each patient with the KQ genotype to a respective control 
      with the KK genotype by gender, age, and duration of diabetes. When compared to 
      matched controls, we observed no significant difference in CAC score (P = 0.959). 
      CONCLUSIONS: The ENPP1 K121Q polymorphism does not appear to be associated with 
      coronary artery calcification in patients with T2DM.
FAU - Jeong, Dae Joon
AU  - Jeong DJ
AD  - Department of Internal Medicine, Kangwon National University Hospital, Kangwon 
      National University School of Medicine, Chuncheon, Korea.
FAU - Lee, Dong Gyu
AU  - Lee DG
FAU - Kim, Hee-Jung
AU  - Kim HJ
FAU - Cho, Eun Hee
AU  - Cho EH
FAU - Kim, Sang-Wook
AU  - Kim SW
LA  - eng
PT  - Journal Article
DEP - 20101031
PL  - Korea (South)
TA  - Korean Diabetes J
JT  - Korean diabetes journal
JID - 101477168
PMC - PMC2972492
OTO - NOTNLM
OT  - Coronary artery calcification
OT  - Diabetes mellitus, type 2
OT  - Ectonucleotide pyrophosphatase phosphodiesterase 1
EDAT- 2010/11/16 06:00
MHDA- 2010/11/16 06:01
PMCR- 2010/10/01
CRDT- 2010/11/16 06:00
PHST- 2010/02/01 00:00 [received]
PHST- 2010/07/23 00:00 [accepted]
PHST- 2010/11/16 06:00 [entrez]
PHST- 2010/11/16 06:00 [pubmed]
PHST- 2010/11/16 06:01 [medline]
PHST- 2010/10/01 00:00 [pmc-release]
AID - 10.4093/kdj.2010.34.5.320 [doi]
PST - ppublish
SO  - Korean Diabetes J. 2010 Oct;34(5):320-6. doi: 10.4093/kdj.2010.34.5.320. Epub 
      2010 Oct 31.