PMID- 21079572
OWN - NLM
STAT- MEDLINE
DCOM- 20110506
LR  - 20131121
IS  - 0026-4784 (Print)
IS  - 0026-4784 (Linking)
VI  - 62
IP  - 6
DP  - 2010 Dec
TI  - [Short-term effect of an estroprogestin containing ethinylestradiol 20 mcg + 
      drospirenone 3 mg in 24+4 regimen at hormonal and cutaneous level in ovarian 
      hyperandrogenism].
PG  - 509-13
AB  - AIM: evaluate the efficacy of an estroprogestin EP containing 20 mcg 
      ethinilestradiol (EE) and 3 mg drospirenone (DRSP) in the treatment of 
      hyperandrogenism. METHODS: In this study, twenty hyperandrogenic patients were 
      treated with an EP containing EE 20 mcg and DRSP 3 mg in 24+4 regimen for three 
      months. Skin evaluation was performed both quantitatively and qualitatively. 
      RESULTS AND CONCLUSION: This EP combination showed, after a short-term treatment 
      (three months) to decrease significantly seborrhea, acne, and circulating 
      androgens (testosterone, deidroepiandrosterone sulphate, and androstenedione), 
      while increased sex hormone binding globulin levels. Moreover, this EE 20 
      mcg/DRSP 3mg EP combination changed some parameters of skin quality, increasing 
      corneometry (a parameter related to skin hydration), and reduced trans epidermal 
      water loss (TEWL, a parameter related to skin evaporation), and erythema (a 
      parameter related to skin inflammation). These results could be taken into 
      account in individualizing the treatment of hyperandrogenic patients.
FAU - Lello, S
AU  - Lello S
AD  - Servizio di Ginecologia Endocrinologica e Fisiopatologia della Menopausa, 
      IRCCS-Istituto Dermopatico dell'Immacolata, Rome, Italia. lellostefano@libero.it
FAU - Pacifico, V
AU  - Pacifico V
FAU - Primavera, G
AU  - Primavera G
FAU - Guardianelli, F
AU  - Guardianelli F
FAU - Sorge, R
AU  - Sorge R
FAU - Paoletti, A M
AU  - Paoletti AM
FAU - Melis, G B
AU  - Melis GB
FAU - Raskovic, D
AU  - Raskovic D
FAU - Colonna, L
AU  - Colonna L
LA  - ita
PT  - English Abstract
PT  - Journal Article
TT  - Effecto a breve termine di un estroprogestinico contenente etinilestradiolo 20 
      mcg+drospirenone 3mg in schema 24 + 4 a livello ormonale e cutaneo 
      nell'iperandrogenismo ovarico.
PL  - Italy
TA  - Minerva Ginecol
JT  - Minerva ginecologica
JID - 0400731
RN  - 0 (Androstenes)
RN  - 0 (Drug Combinations)
RN  - 0 (Estrogens)
RN  - 0 (Mineralocorticoid Receptor Antagonists)
RN  - 0 (Norpregnenes)
RN  - 0 (estroprogestin)
RN  - 423D2T571U (Ethinyl Estradiol)
RN  - N295J34A25 (drospirenone)
SB  - IM
MH  - Administration, Oral
MH  - Adolescent
MH  - Adult
MH  - Androstenes/*administration & dosage
MH  - Drug Combinations
MH  - Estrogens/*administration & dosage
MH  - Ethinyl Estradiol/*administration & dosage
MH  - Female
MH  - Humans
MH  - Hyperandrogenism/diagnosis/*drug therapy
MH  - Mineralocorticoid Receptor Antagonists/*administration & dosage
MH  - *Norpregnenes
MH  - Severity of Illness Index
MH  - Time Factors
MH  - Treatment Outcome
EDAT- 2010/11/17 06:00
MHDA- 2011/05/07 06:00
CRDT- 2010/11/17 06:00
PHST- 2010/11/17 06:00 [entrez]
PHST- 2010/11/17 06:00 [pubmed]
PHST- 2011/05/07 06:00 [medline]
AID - R09103205 [pii]
PST - ppublish
SO  - Minerva Ginecol. 2010 Dec;62(6):509-13.