PMID- 21080183
OWN - NLM
STAT- MEDLINE
DCOM- 20110613
LR  - 20211020
IS  - 1432-1750 (Electronic)
IS  - 0341-2040 (Linking)
VI  - 189
IP  - 1
DP  - 2011 Feb
TI  - Oxygen uptake, ventilation, and symptoms during low-frequency versus 
      high-frequency NMES in COPD: a pilot study.
PG  - 21-6
LID - 10.1007/s00408-010-9265-0 [doi]
AB  - Transcutaneous neuromuscular electrical stimulation (NMES) involves the 
      application of an electrical current through electrodes placed on the skin over 
      the targeted muscles. During high-frequency NMES (HF-NMES), oxygen uptake, minute 
      ventilation, and the degree of symptom perception (dyspnea and fatigue) have been 
      shown to be acceptable in chronic obstructive pulmonary disease (COPD). 
      Currently, oxygen uptake and ventilation load have never been assessed during 
      low-frequency NMES (LF-NMES) of the lower-limb muscles. The purpose of this study 
      was to compare prospectively oxygen uptake, ventilation, and symptom perception 
      during a single session of LF-NMES versus a single session of HF-NMES of 
      quadriceps muscles in patients with COPD. In 17 COPD patients (mean FEV(1) = 45% 
      predicted, mean body mass index = 26.2 kg/m(2)), peak exercise capacity, 
      functional exercise capacity, and the Medical Research Council dyspnea grade were 
      evaluated. In addition, oxygen uptake, minute ventilation, heart rate, and Borg 
      symptom scores were assessed during one session of LF-NMES (15 Hz) and one 
      session of HF-NMES (75 Hz) and compared with peak values. Mean oxygen uptake 
      (LF-NMES: 327 ml/min vs. HF-NMES: 315 ml/min), minute ventilation (LF-NMES: 14 L 
      vs. HF-NMES: 15 L), and heart rate (LF-NMES: 86 BPM vs. HF-NMES: 83 BPM) were 
      similar during both NMES frequencies. Patients used a relatively low proportion 
      of their peak aerobic capacity during both NMES sessions (LF-NMES: 34% vs. 
      HF-NMES: 33%; P = 0.397). In addition, symptom Borg scores for dyspnea and leg 
      fatigue were also comparable. Oxygen uptake, ventilation, and symptoms of dyspnea 
      and fatigue were comparable and tolerable during LF-NMES and HF-NMES in patients 
      with COPD. Therefore, LF-NMES and HF-NMES may both be suitable rehabilitative 
      modalities to be used in severely dyspneic patients with lower-limb muscle 
      dysfunction.
FAU - Sillen, Maurice J H
AU  - Sillen MJ
AD  - Program Development Centre, Ciro+, Hornerheide 1, Horn, The Netherlands. 
      mauricesillen@ciro-horn.nl
FAU - Wouters, Emiel F M
AU  - Wouters EF
FAU - Franssen, Frits M E
AU  - Franssen FM
FAU - Meijer, Kenneth
AU  - Meijer K
FAU - Stakenborg, Koen H P
AU  - Stakenborg KH
FAU - Spruit, Martijn A
AU  - Spruit MA
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Randomized Controlled Trial
PT  - Research Support, Non-U.S. Gov't
DEP - 20101116
PL  - United States
TA  - Lung
JT  - Lung
JID - 7701875
RN  - S88TT14065 (Oxygen)
SB  - IM
MH  - Aged
MH  - Cross-Over Studies
MH  - Dyspnea/etiology/therapy
MH  - Exercise Tolerance
MH  - Female
MH  - Forced Expiratory Volume
MH  - Heart Rate
MH  - Humans
MH  - Lung/metabolism/*physiopathology
MH  - Male
MH  - Middle Aged
MH  - Muscle Fatigue
MH  - Netherlands
MH  - Oxygen/*metabolism
MH  - Pilot Projects
MH  - Prospective Studies
MH  - Pulmonary Disease, Chronic 
      Obstructive/complications/metabolism/physiopathology/*therapy
MH  - *Pulmonary Ventilation
MH  - Quadriceps Muscle/*innervation
MH  - Respiratory Mechanics
MH  - Transcutaneous Electric Nerve Stimulation/adverse effects/*methods
MH  - Treatment Outcome
EDAT- 2010/11/17 06:00
MHDA- 2011/06/15 06:00
CRDT- 2010/11/17 06:00
PHST- 2010/09/15 00:00 [received]
PHST- 2010/10/25 00:00 [accepted]
PHST- 2010/11/17 06:00 [entrez]
PHST- 2010/11/17 06:00 [pubmed]
PHST- 2011/06/15 06:00 [medline]
AID - 10.1007/s00408-010-9265-0 [doi]
PST - ppublish
SO  - Lung. 2011 Feb;189(1):21-6. doi: 10.1007/s00408-010-9265-0. Epub 2010 Nov 16.