PMID- 2108084
OWN - NLM
STAT- MEDLINE
DCOM- 19900503
LR  - 20210526
IS  - 0019-9567 (Print)
IS  - 1098-5522 (Electronic)
IS  - 0019-9567 (Linking)
VI  - 58
IP  - 4
DP  - 1990 Apr
TI  - Effect of environmental conditions on production of toxic shock syndrome toxin 1 
      by Staphylococcus aureus.
PG  - 1026-9
AB  - The kinetics of toxic shock syndrome toxin 1 (TSST-1) production by 
      Staphylococcus aureus was studied in a fermentor in which aeration rate, 
      atmospheric composition, pH, and temperature were controlled. The toxin was 
      synthesized at a maximal rate during the exponential phase. High bacterial 
      populations were not necessarily accompanied by high TSST-1 yields. Aerobiosis 
      increased TSST-1 production, but excessive aeration had an adverse effect. 
      Addition of CO2 enhanced TSST-1 yield by increasing toxin production rate and 
      efficiency. Cultures with no pH control made more TSST-1 than those maintained at 
      pH 5.5 to 7.5. Maximum TSST-1 yields were obtained when cultures were supplied 
      with air (20 cm3/min) and CO2 (5 cm3/min) via a sintered glass sparger.
FAU - Wong, A C
AU  - Wong AC
AD  - Food Research Institute, University of Wisconsin, Madison 53706.
FAU - Bergdoll, M S
AU  - Bergdoll MS
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Infect Immun
JT  - Infection and immunity
JID - 0246127
RN  - 0 (Bacterial Toxins)
RN  - 0 (Culture Media)
RN  - 0 (Enterotoxins)
RN  - 0 (Superantigens)
RN  - 0 (enterotoxin F, Staphylococcal)
RN  - 142M471B3J (Carbon Dioxide)
RN  - S88TT14065 (Oxygen)
SB  - IM
MH  - *Bacterial Toxins
MH  - Carbon Dioxide/pharmacology
MH  - Culture Media
MH  - Enterotoxins/*biosynthesis
MH  - Oxygen/pharmacology
MH  - Staphylococcus aureus/*metabolism
MH  - *Superantigens
PMC - PMC258577
EDAT- 1990/04/01 00:00
MHDA- 1990/04/01 00:01
PMCR- 1990/04/01
CRDT- 1990/04/01 00:00
PHST- 1990/04/01 00:00 [pubmed]
PHST- 1990/04/01 00:01 [medline]
PHST- 1990/04/01 00:00 [entrez]
PHST- 1990/04/01 00:00 [pmc-release]
AID - 10.1128/iai.58.4.1026-1029.1990 [doi]
PST - ppublish
SO  - Infect Immun. 1990 Apr;58(4):1026-9. doi: 10.1128/iai.58.4.1026-1029.1990.