PMID- 21081959
OWN - NLM
STAT- MEDLINE
DCOM- 20110422
LR  - 20110202
IS  - 1476-5640 (Electronic)
IS  - 0954-3007 (Linking)
VI  - 65
IP  - 2
DP  - 2011 Feb
TI  - A non-hydrolyzed, fermented milk formula reduces digestive and respiratory events 
      in infants at high risk of allergy.
PG  - 175-83
LID - 10.1038/ejcn.2010.250 [doi]
AB  - BACKGROUND/OBJECTIVES: To determine the impact of a not hydrolyzed fermented 
      infant formula containing heat-killed Bifidobacterium breve C50 and Streptococcus 
      thermophilus 065 (HKBBST) on the incidence of allergy-like events during the 
      first 2 years of life in children at high risk of atopy. SUBJECTS/METHODS: This 
      multicenter, randomized, double-blind, controlled study included infants at high 
      risk of atopy. Infants used HKBBST or a standard infant formula (SIF) since birth 
      until 1 year of age, and were followed at 4, 12 and 24 months after birth. Skin 
      prick tests (SPTs) for six foods and six aeroallergens were systematically 
      performed and adverse events (AEs) were recorded. In case of potentially allergic 
      AE (PAAE), allergy could be further tested by SPT, patch tests and quantification 
      of specific IgEs. If cow's milk allergy (CMA) was suspected, an oral challenge 
      could also be performed. RESULTS: The study included 129 children, 63 were 
      randomized to SIF, 66 to HKBBST. The use of HKBBST milk did not alter the 
      proportion of CMA but decreased the proportion of positive SPT to cow's milk (1.7 
      vs 12.5%, P=0.03), and the incidence of digestive (39 vs 63%, P=0.01) and 
      respiratory potentially allergic AEs (7 vs 21%, P=0.03) at 12 months, and that of 
      respiratory PAAEs at 24 months (13 vs 35%, P=0.01). CONCLUSIONS: HKBBST decreased 
      the incidence of PAAEs in children with family history of atopy, during the first 
      months of life and after the formula was stopped. Oral tolerance to cow's milk in 
      infants at high risk of atopy may therefore be improved using not hydrolyzed 
      fermented formulae.
FAU - Morisset, M
AU  - Morisset M
AD  - Medecine Interne, Immunologie Clinique et Allergologie, CHU de Nancy, Allergic 
      Diseases: Diagnostic and Therapy, Nancy University, Nancy, France.
FAU - Aubert-Jacquin, C
AU  - Aubert-Jacquin C
FAU - Soulaines, P
AU  - Soulaines P
FAU - Moneret-Vautrin, D-A
AU  - Moneret-Vautrin DA
FAU - Dupont, C
AU  - Dupont C
LA  - eng
PT  - Journal Article
PT  - Multicenter Study
PT  - Randomized Controlled Trial
PT  - Research Support, Non-U.S. Gov't
DEP - 20101117
PL  - England
TA  - Eur J Clin Nutr
JT  - European journal of clinical nutrition
JID - 8804070
SB  - IM
MH  - Bifidobacterium/growth & development/*physiology
MH  - Cultured Milk Products/*immunology/microbiology
MH  - Digestive System Diseases/epidemiology/prevention & control
MH  - Double-Blind Method
MH  - Female
MH  - Food Hypersensitivity/epidemiology/prevention & control
MH  - Humans
MH  - Hypersensitivity, Immediate/epidemiology/prevention & control
MH  - Infant
MH  - Infant Food
MH  - Infant Formula/*administration & dosage
MH  - Infant, Newborn
MH  - Male
MH  - Milk Hypersensitivity/prevention & control
MH  - Probiotics/administration & dosage
MH  - Respiratory Tract Diseases/epidemiology/prevention & control
MH  - Streptococcus thermophilus/growth & development/*physiology
EDAT- 2010/11/18 06:00
MHDA- 2011/04/26 06:00
CRDT- 2010/11/18 06:00
PHST- 2010/11/18 06:00 [entrez]
PHST- 2010/11/18 06:00 [pubmed]
PHST- 2011/04/26 06:00 [medline]
AID - ejcn2010250 [pii]
AID - 10.1038/ejcn.2010.250 [doi]
PST - ppublish
SO  - Eur J Clin Nutr. 2011 Feb;65(2):175-83. doi: 10.1038/ejcn.2010.250. Epub 2010 Nov 
      17.