PMID- 21087324
OWN - NLM
STAT- MEDLINE
DCOM- 20110419
LR  - 20101122
IS  - 1600-0625 (Electronic)
IS  - 0906-6705 (Linking)
VI  - 19
IP  - 12
DP  - 2010 Dec
TI  - Strong exercise stress exacerbates dermatitis in atopic model mice, NC/Nga mice, 
      while proper exercise reduces it.
PG  - 1067-72
LID - 10.1111/j.1600-0625.2010.01130.x [doi]
AB  - Atopic dermatitis is well known to exacerbate by stress. How the influence of 
      exercise stress on the skin symptoms in patients with atopic dermatitis has not 
      been clarified. The purpose of our research is to investigate how different 
      strength of exercise stress acts on atopic dermatitis. Specific pathogen-free 
      (SPF) and conventional NC/Nga male mice were used for the experiments. 
      Conventional mice but not SPF group spontaneously develop dermal symptom similar 
      to that of patients with atopic dermatitis at their age of 7 weeks. They were 
      given two types of stress, mild (20 m/min for 60 min) or strong exercise (25 
      m/min for 90 min), using a treadmill four times per day. The dermal symptom of 
      the conventional group was strongly exacerbated by strong exercise but 
      ameliorated by mild exercise. Under the standard experimental conditions, plasma 
      concentrations of alpha-melanocyte-stimulating hormone (alpha-MSH), transforming growth 
      factor-beta (TGF-beta) and substance P in conventional mice increased markedly with 
      concomitant exacerbation of the symptom. The plasma concentrations of these 
      proteins elevated after strong exercise but decreased after mild exercise. Under 
      the conventional conditions, plasma levels of beta-endorphin increased with time by 
      some mechanisms enhanced by the mild exercise. These observations suggested that 
      exercise-induced stress significantly affect the symptom of atopic dermatitis in 
      a pivotal manner depending on the plasma levels of TGF-beta, alpha-MSH, substance P and 
      beta-endorphin.
CI  - (c) 2010 John Wiley & Sons A/S.
FAU - Orita, Kumi
AU  - Orita K
AD  - Department of Biochemistry and Molecular Pathology, Osaka City University Medical 
      School, Abeno, Osaka, Japan.
FAU - Hiramoto, Keiichi
AU  - Hiramoto K
FAU - Inoue, Risa
AU  - Inoue R
FAU - Sato, Eisuke F
AU  - Sato EF
FAU - Kobayashi, Hiromi
AU  - Kobayashi H
FAU - Ishii, Masamitsu
AU  - Ishii M
FAU - Inoue, Masayasu
AU  - Inoue M
LA  - eng
PT  - Journal Article
DEP - 20100907
PL  - Denmark
TA  - Exp Dermatol
JT  - Experimental dermatology
JID - 9301549
RN  - 0 (Transforming Growth Factor beta)
RN  - 0 (Tumor Necrosis Factor-alpha)
RN  - 33507-63-0 (Substance P)
RN  - 37341-29-0 (Immunoglobulin E)
RN  - 581-05-5 (alpha-MSH)
RN  - 60617-12-1 (beta-Endorphin)
RN  - 9002-60-2 (Adrenocorticotropic Hormone)
SB  - IM
MH  - Adrenocorticotropic Hormone/blood
MH  - Animals
MH  - Dermatitis, Atopic/blood/diagnosis/*etiology/metabolism/pathology
MH  - Exercise Test
MH  - Immunoglobulin E/blood
MH  - Male
MH  - Mice
MH  - Mice, Inbred Strains
MH  - Physical Conditioning, Animal/*physiology
MH  - Skin/metabolism/pathology
MH  - Specific Pathogen-Free Organisms
MH  - Stress, Physiological/*physiology
MH  - Substance P/metabolism
MH  - Transforming Growth Factor beta/blood
MH  - Tumor Necrosis Factor-alpha/blood
MH  - alpha-MSH/blood
MH  - beta-Endorphin/metabolism
EDAT- 2010/11/23 06:00
MHDA- 2011/04/20 06:00
CRDT- 2010/11/20 06:00
PHST- 2010/11/20 06:00 [entrez]
PHST- 2010/11/23 06:00 [pubmed]
PHST- 2011/04/20 06:00 [medline]
AID - 10.1111/j.1600-0625.2010.01130.x [doi]
PST - ppublish
SO  - Exp Dermatol. 2010 Dec;19(12):1067-72. doi: 10.1111/j.1600-0625.2010.01130.x. 
      Epub 2010 Sep 7.