PMID- 21088176
OWN - NLM
STAT- MEDLINE
DCOM- 20110203
LR  - 20190522
IS  - 1040-6387 (Print)
IS  - 1040-6387 (Linking)
VI  - 22
IP  - 6
DP  - 2010 Nov
TI  - Histologic and bacteriologic findings in valvular endocarditis of slaughter-age 
      pigs.
PG  - 921-7
AB  - Endocarditis lesions from 117 slaughter pigs were examined pathologically and 
      etiologically in addition to 90 control hearts with cardiac valves. Lesions were 
      located on the valves; however, the lesions had extended to the walls in 21 cases 
      (18%). Lesions predominated on the mitral valve (59%). A total of 28 cases, from 
      which no growth was obtained or a contamination flora was grown, were screened by 
      fluorescence in situ hybridization (FISH) for bacteria (general bacterial probe) 
      and probes specific for Streptococcus suis and Erysipelothrix rhusiopathiae, 
      respectively. Using FISH, an additional 10 cases of endocarditis due to S. suis 
      and E. rhusiopathiae were disclosed. Within lesions, streptococci predominated 
      (53%) followed by E. rhusiopathiae (30%). Distinct features of both the lesions 
      and the shape and localization of bacterial colonies were related to streptococci 
      and E. rhusiopathiae. The propensity for streptococci to be localized on more 
      than 1 valve in single hearts may be because S. suis-infected pigs tend to have 
      been infected for a longer period compared with E. rhusiopathiae. Mineralization 
      of endocarditis lesions was significantly associated with infection by 
      streptococci, and was seen in 71% of the cases, whereas it was present in only 
      28% of lesions caused by E. rhusiopathiae. In addition, areas with mineralization 
      were significantly correlated to the presence of a granulomatous reaction. 
      Granulomatous endocarditis is likely a result of a foreign body reaction due to 
      dystrophic mineralization. Local proliferation of valvular endothelial cells, 
      found in 9 hearts in the current study, may increase the risk of developing 
      thrombosing endocarditis in pigs.
FAU - Jensen, Henrik E
AU  - Jensen HE
AD  - Department of Veterinary Disease Biology, Faculty of Life Sciences, University of 
      Copenhagen, Ridebanevej 3, DK-1870 Frederiksberg C, Denmark. elvang@life.ku.dk
FAU - Gyllensten, Johanna
AU  - Gyllensten J
FAU - Hofman, Carolina
AU  - Hofman C
FAU - Leifsson, Pall S
AU  - Leifsson PS
FAU - Agerholm, Jorgen S
AU  - Agerholm JS
FAU - Boye, Mette
AU  - Boye M
FAU - Aalbaek, Bent
AU  - Aalbaek B
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - J Vet Diagn Invest
JT  - Journal of veterinary diagnostic investigation : official publication of the 
      American Association of Veterinary Laboratory Diagnosticians, Inc
JID - 9011490
SB  - IM
MH  - *Aging
MH  - Animals
MH  - Endocarditis, Bacterial/microbiology/pathology/*veterinary
MH  - Erysipelothrix/isolation & purification
MH  - Erysipelothrix Infections/pathology
MH  - Heart Valve Diseases/microbiology/pathology/*veterinary
MH  - Streptococcal Infections/pathology/veterinary
MH  - Streptococcus suis/isolation & purification
MH  - Swine
MH  - Swine Diseases/*microbiology/pathology
EDAT- 2010/11/23 06:00
MHDA- 2011/02/04 06:00
CRDT- 2010/11/20 06:00
PHST- 2010/11/20 06:00 [entrez]
PHST- 2010/11/23 06:00 [pubmed]
PHST- 2011/02/04 06:00 [medline]
AID - 22/6/921 [pii]
AID - 10.1177/104063871002200611 [doi]
PST - ppublish
SO  - J Vet Diagn Invest. 2010 Nov;22(6):921-7. doi: 10.1177/104063871002200611.