PMID- 21088708
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20110714
LR  - 20211020
IS  - 1662-5161 (Electronic)
IS  - 1662-5161 (Linking)
VI  - 4
DP  - 2010
TI  - Brain Activations to Emotional Pictures are Differentially Associated with 
      Valence and Arousal Ratings.
PG  - 175
LID - 10.3389/fnhum.2010.00175 [doi]
LID - 175
AB  - Several studies have investigated the neural responses triggered by emotional 
      pictures, but the specificity of the involved structures such as the amygdala or 
      the ventral striatum is still under debate. Furthermore, only few studies 
      examined the association of stimuli's valence and arousal and the underlying 
      brain responses. Therefore, we investigated brain responses with functional 
      magnetic resonance imaging of 17 healthy participants to pleasant and unpleasant 
      affective pictures and afterwards assessed ratings of valence and arousal. As 
      expected, unpleasant pictures strongly activated the right and left amygdala, the 
      right hippocampus, and the medial occipital lobe, whereas pleasant pictures 
      elicited significant activations in left occipital regions, and in parts of the 
      medial temporal lobe. The direct comparison of unpleasant and pleasant pictures, 
      which were comparable in arousal clearly indicated stronger amygdala activation 
      in response to the unpleasant pictures. Most important, correlational analyses 
      revealed on the one hand that the arousal of unpleasant pictures was 
      significantly associated with activations in the right amygdala and the left 
      caudate body. On the other hand, valence of pleasant pictures was significantly 
      correlated with activations in the right caudate head, extending to the nucleus 
      accumbens (NAcc) and the left dorsolateral prefrontal cortex. These findings 
      support the notion that the amygdala is primarily involved in processing of 
      unpleasant stimuli, particularly to more arousing unpleasant stimuli. 
      Reward-related structures like the caudate and NAcc primarily respond to pleasant 
      stimuli, the stronger the more positive the valence of these stimuli is.
FAU - Gerdes, Antje B M
AU  - Gerdes AB
AD  - Department of Psychology, University of Wurzburg Wurzburg, Germany.
FAU - Wieser, Matthias J
AU  - Wieser MJ
FAU - Muhlberger, Andreas
AU  - Muhlberger A
FAU - Weyers, Peter
AU  - Weyers P
FAU - Alpers, Georg W
AU  - Alpers GW
FAU - Plichta, Michael M
AU  - Plichta MM
FAU - Breuer, Felix
AU  - Breuer F
FAU - Pauli, Paul
AU  - Pauli P
LA  - eng
PT  - Journal Article
DEP - 20101028
PL  - Switzerland
TA  - Front Hum Neurosci
JT  - Frontiers in human neuroscience
JID - 101477954
PMC - PMC2982745
OTO - NOTNLM
OT  - amygdala
OT  - arousal
OT  - caudate
OT  - emotional pictures
OT  - valence
EDAT- 2010/11/23 06:00
MHDA- 2010/11/23 06:01
PMCR- 2010/01/01
CRDT- 2010/11/20 06:00
PHST- 2010/05/25 00:00 [received]
PHST- 2010/08/23 00:00 [accepted]
PHST- 2010/11/20 06:00 [entrez]
PHST- 2010/11/23 06:00 [pubmed]
PHST- 2010/11/23 06:01 [medline]
PHST- 2010/01/01 00:00 [pmc-release]
AID - 10.3389/fnhum.2010.00175 [doi]
PST - epublish
SO  - Front Hum Neurosci. 2010 Oct 28;4:175. doi: 10.3389/fnhum.2010.00175. eCollection 
      2010.