PMID- 21089160
OWN - NLM
STAT- MEDLINE
DCOM- 20110916
LR  - 20131121
IS  - 1099-1263 (Electronic)
IS  - 0260-437X (Linking)
VI  - 31
IP  - 4
DP  - 2011 May
TI  - Different reaction patterns of dopamine content to prenatal exposure to 
      chlorpyrifos in different periods.
PG  - 355-9
LID - 10.1002/jat.1598 [doi]
AB  - Developmental exposure to chlorpyrifos (CPF) induces abnormalities in 
      neurotransmission. In the present study, we evaluated the dopamine reaction 
      patterns in brain regions after CPF exposure during different prenatal periods. 
      Animals were exposed on gestational days (GD) 7.5-11.5 or 13-17 and assessed at 
      GD17, and at postnatal days (PN) 14 and 60. CPF exposure during GD7.5-11.5 
      elicited a decrease in dopamine content at each measurement stages, with more 
      changes in the hippocampus than in the cerebral cortex. In contrast, CPF exposure 
      in GD13-17 elicited a decrease in dopamine content at PN14 and PN60, with more 
      changes in the cerebral cortex than in the hippocampus. These results suggest 
      that the two key brain regions involved in learning and memory, the cerebral 
      cortex and hippocampus, react differently to CPF exposure in different prenatal 
      periods. The abnormalities did not recover long after cessation of CPF exposure 
      and deficiencies persisted into pre-puberty and adulthood.
CI  - Copyright (c) 2010 John Wiley & Sons, Ltd.
FAU - Chen, Xiao-Ping
AU  - Chen XP
AD  - College of Biological and Environmental Engineering, Zhejiang University of 
      Technology, 18 Chao-Wang Road, Hangzhou 310032, China. chxp@zjut.edu.cn
FAU - Wang, Xiang
AU  - Wang X
FAU - Dong, Jing-Yin
AU  - Dong JY
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20101119
PL  - England
TA  - J Appl Toxicol
JT  - Journal of applied toxicology : JAT
JID - 8109495
RN  - 0 (Insecticides)
RN  - JCS58I644W (Chlorpyrifos)
RN  - VTD58H1Z2X (Dopamine)
SB  - IM
MH  - Animals
MH  - Brain/*drug effects/embryology/growth & development/metabolism
MH  - Chlorpyrifos/*toxicity
MH  - Dopamine/*metabolism
MH  - Female
MH  - Gestational Age
MH  - Insecticides/*toxicity
MH  - Male
MH  - Mice
MH  - Mice, Inbred ICR
MH  - Neurogenesis/*drug effects
MH  - Pregnancy
MH  - Prenatal Exposure Delayed Effects/*chemically induced/metabolism
EDAT- 2010/11/23 06:00
MHDA- 2011/09/17 06:00
CRDT- 2010/11/20 06:00
PHST- 2010/05/10 00:00 [received]
PHST- 2010/06/23 00:00 [revised]
PHST- 2010/08/22 00:00 [accepted]
PHST- 2010/11/20 06:00 [entrez]
PHST- 2010/11/23 06:00 [pubmed]
PHST- 2011/09/17 06:00 [medline]
AID - 10.1002/jat.1598 [doi]
PST - ppublish
SO  - J Appl Toxicol. 2011 May;31(4):355-9. doi: 10.1002/jat.1598. Epub 2010 Nov 19.