PMID- 21090747
OWN - NLM
STAT- MEDLINE
DCOM- 20110210
LR  - 20220321
IS  - 1520-5851 (Electronic)
IS  - 0013-936X (Linking)
VI  - 44
IP  - 24
DP  - 2010 Dec 15
TI  - Changes in concentrations of perfluorinated compounds, polybrominated diphenyl 
      ethers, and polychlorinated biphenyls in Norwegian breast-milk during twelve 
      months of lactation.
PG  - 9550-6
LID - 10.1021/es1021922 [doi]
AB  - At present, scientific knowledge on depuration rates of persistent organic 
      pollutants (POPs) is limited and the previous assumptions of considerable 
      reduction of body burdens through breast-feeding have recently been challenged. 
      We therefore studied elimination rates of important POPs in nine Norwegian 
      primiparous mothers and one mother breast-feeding her second child by collecting 
      breast-milk samples (n = 70) monthly from about two weeks to up to twelve months 
      after birth. Perfluorinated compounds (PFCs), polybrominated diphenyl ethers 
      (PBDEs), hexabromocyclododecane (HBCD), and polychlorinated biphenyls (PCBs) were 
      determined in the breast-milk samples. Linear mixed effect models were 
      established for selected compounds, and significant decreases in the range of 
      1.2-4.7% in breast-milk concentrations per month were observed for a wide range 
      of PCBs and PBDEs. For the first time, depuration rates for 
      perfluorooctylsulfonate (PFOS) and perfluorooctanoic acid (PFOA) are presented, 
      being 3.8 and 7.8% per month, respectively (p < 0.05). The relative amount of the 
      branched PFOS isomers in the breast-milk samples was 18% on average (range 6-36%, 
      RSD 30%). There were no significant differences in isomer pattern between the 
      mothers, or changes during the lactation period. After a year of nursing the 
      breast-milk concentrations of PFCs, PBDEs, and PCBs were reduced by 15-94%.
FAU - Thomsen, Cathrine
AU  - Thomsen C
AD  - Department of Analytical Chemistry, Division of Environmental Medicine, Norwegian 
      Institute of Public Health, PO Box 4404 Nydalen, NO-0403 Oslo, Norway. 
      cathrine.thomsen@fhi.no
FAU - Haug, Line S
AU  - Haug LS
FAU - Stigum, Hein
AU  - Stigum H
FAU - Froshaug, May
AU  - Froshaug M
FAU - Broadwell, Sharon L
AU  - Broadwell SL
FAU - Becher, Georg
AU  - Becher G
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20101123
PL  - United States
TA  - Environ Sci Technol
JT  - Environmental science & technology
JID - 0213155
RN  - 0 (Alkanesulfonic Acids)
RN  - 0 (Caprylates)
RN  - 0 (Environmental Pollutants)
RN  - 0 (Fluorocarbons)
RN  - 0 (Halogenated Diphenyl Ethers)
RN  - 0 (Hydrocarbons, Fluorinated)
RN  - 947VD76D3L (perfluorooctanoic acid)
RN  - 9H2MAI21CL (perfluorooctane sulfonic acid)
RN  - DFC2HB4I0K (Polychlorinated Biphenyls)
SB  - IM
EIN - Environ Sci Technol. 2011 Apr 1;45(7):3192
MH  - Adult
MH  - Alkanesulfonic Acids/metabolism
MH  - Breast Feeding
MH  - Caprylates/metabolism
MH  - Environmental Monitoring
MH  - Environmental Pollutants/*metabolism
MH  - Female
MH  - Fluorocarbons/metabolism
MH  - Halogenated Diphenyl Ethers/*metabolism
MH  - Humans
MH  - Hydrocarbons, Fluorinated/*metabolism
MH  - Maternal Exposure/statistics & numerical data
MH  - Milk, Human/*metabolism
MH  - Mothers
MH  - Norway
MH  - Polychlorinated Biphenyls/*metabolism
EDAT- 2010/11/26 06:00
MHDA- 2011/02/11 06:00
CRDT- 2010/11/25 06:00
PHST- 2010/11/25 06:00 [entrez]
PHST- 2010/11/26 06:00 [pubmed]
PHST- 2011/02/11 06:00 [medline]
AID - 10.1021/es1021922 [doi]
PST - ppublish
SO  - Environ Sci Technol. 2010 Dec 15;44(24):9550-6. doi: 10.1021/es1021922. Epub 2010 
      Nov 23.