PMID- 21091895
OWN - NLM
STAT- MEDLINE
DCOM- 20110310
LR  - 20181201
IS  - 1751-2980 (Electronic)
IS  - 1751-2972 (Linking)
VI  - 11
IP  - 6
DP  - 2010 Dec
TI  - Controversy of proton pump inhibitor and clopidogrel interaction: a review.
PG  - 334-42
LID - 10.1111/j.1751-2980.2010.00466.x [doi]
AB  - A proton pump inhibitor (PPI) is often co-prescribed with clopidogrel to reduce 
      the gastrointestinal risk of bleeding ulcers in patients following acute coronary 
      syndrome or a stent implant. However, the safety issue of such practice has been 
      scrutinized after some studies reporting an increased incidence of cardiovascular 
      events and mortality, although there have also been contrary research reports. 
      This has lead to a warning statement from the US Food and Drug Administration 
      cautioning the concomitant use of PPI and clopidogrel. This review examines the 
      evidence of PPI as gastroprotective agent, histamine H(2) antagonists as an 
      alternative therapy, the influence of PPI on the antiplatelet effect of 
      clopidogrel, and the controversies of various studies.
CI  - (c) 2010 Chinese Medical Association Shanghai Branch, Chinese Society of 
      Gastroenterology, Renji Hospital Affiliated to Shanghai Jiaotong University 
      School of Medicine and Blackwell Publishing Asia Pty Ltd.
FAU - Tan, H J
AU  - Tan HJ
AD  - Division of Gastroenterology, Sunway Medical Centre, Kuala Lumpur, Malaysia. 
      hucktan@hotmail.com
LA  - eng
PT  - Journal Article
PT  - Review
PL  - Australia
TA  - J Dig Dis
JT  - Journal of digestive diseases
JID - 101302699
RN  - 0 (Platelet Aggregation Inhibitors)
RN  - 0 (Proton Pump Inhibitors)
RN  - A74586SNO7 (Clopidogrel)
RN  - OM90ZUW7M1 (Ticlopidine)
SB  - IM
MH  - Acute Coronary Syndrome/*drug therapy/epidemiology
MH  - Clopidogrel
MH  - Drug Interactions
MH  - Humans
MH  - Platelet Aggregation Inhibitors/administration & dosage/*adverse effects
MH  - Proton Pump Inhibitors/administration & dosage/*adverse effects
MH  - Risk Factors
MH  - Stomach Ulcer/epidemiology/*prevention & control
MH  - Ticlopidine/administration & dosage/adverse effects/*analogs & derivatives
EDAT- 2010/11/26 06:00
MHDA- 2011/03/11 06:00
CRDT- 2010/11/25 06:00
PHST- 2010/11/25 06:00 [entrez]
PHST- 2010/11/26 06:00 [pubmed]
PHST- 2011/03/11 06:00 [medline]
AID - 10.1111/j.1751-2980.2010.00466.x [doi]
PST - ppublish
SO  - J Dig Dis. 2010 Dec;11(6):334-42. doi: 10.1111/j.1751-2980.2010.00466.x.