PMID- 21093980
OWN - NLM
STAT- MEDLINE
DCOM- 20110407
LR  - 20110221
IS  - 1872-7980 (Electronic)
IS  - 0304-3835 (Linking)
VI  - 302
IP  - 2
DP  - 2011 Mar 28
TI  - Melanoma-associated antigen genes - an update.
PG  - 85-90
LID - 10.1016/j.canlet.2010.10.021 [doi]
AB  - To date, dozens of melanoma-associated antigens (MAGE) have been identified. 
      Based on the differences in tissue-specific gene expression and gene structure, 
      the MAGE family has been divided into two big subfamilies: MAGE-I and MAGE-II. 
      MAGE-I genes were identified as a group of highly attractive targets for cancer 
      immunotherapy because of their wide expression in a variety of malignant tumors 
      but silent in normal adult cells except germ-line cells lacking human leukocyte 
      antigen (HLA) expression. However, little is known regarding the functions of 
      MAGE family members in cell activities. In this review, we briefly described the 
      classification of MAGE family members and their expression pattern in cancer. We 
      also summarized the mechanism of MAGE activation and the functions of MAGE family 
      members in cell cycle progression and apoptosis. We also discussed what is known 
      of immunotherapy targeting MAGE family.
CI  - Copyright (c) 2010 Elsevier Ireland Ltd. All rights reserved.
FAU - Sang, Meixiang
AU  - Sang M
AD  - Tumor Research Institute, the Fourth Hospital of Hebei Medical University, 
      Shijiazhuang, Hebei 050017, PR China.
FAU - Wang, Lifang
AU  - Wang L
FAU - Ding, Chunyan
AU  - Ding C
FAU - Zhou, Xinliang
AU  - Zhou X
FAU - Wang, Bin
AU  - Wang B
FAU - Wang, Ling
AU  - Wang L
FAU - Lian, Yishui
AU  - Lian Y
FAU - Shan, Baoen
AU  - Shan B
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20101119
PL  - Ireland
TA  - Cancer Lett
JT  - Cancer letters
JID - 7600053
RN  - 0 (Antigens, Neoplasm)
RN  - 0 (Antineoplastic Agents)
RN  - 0 (MAGE-A10 antigen)
RN  - 0 (Melanoma-Specific Antigens)
RN  - 0 (Neoplasm Proteins)
SB  - IM
MH  - Antigens, Neoplasm/genetics
MH  - Antineoplastic Agents/therapeutic use
MH  - Drug Delivery Systems
MH  - Female
MH  - Humans
MH  - Immunotherapy
MH  - Male
MH  - Melanoma/drug therapy/*genetics/immunology
MH  - Melanoma-Specific Antigens/classification/*genetics
MH  - Neoplasm Proteins/genetics
EDAT- 2010/11/26 06:00
MHDA- 2011/04/08 06:00
CRDT- 2010/11/25 06:00
PHST- 2010/08/25 00:00 [received]
PHST- 2010/10/20 00:00 [revised]
PHST- 2010/10/22 00:00 [accepted]
PHST- 2010/11/25 06:00 [entrez]
PHST- 2010/11/26 06:00 [pubmed]
PHST- 2011/04/08 06:00 [medline]
AID - S0304-3835(10)00506-9 [pii]
AID - 10.1016/j.canlet.2010.10.021 [doi]
PST - ppublish
SO  - Cancer Lett. 2011 Mar 28;302(2):85-90. doi: 10.1016/j.canlet.2010.10.021. Epub 
      2010 Nov 19.