PMID- 21094356
OWN - NLM
STAT- MEDLINE
DCOM- 20110120
LR  - 20101124
IS  - 1879-1913 (Electronic)
IS  - 0002-9149 (Linking)
VI  - 106
IP  - 11
DP  - 2010 Dec 1
TI  - Predictors of death and occurrence of appropriate implantable defibrillator 
      therapies in patients with ischemic cardiomyopathy.
PG  - 1566-73
LID - 10.1016/j.amjcard.2010.07.029 [doi]
AB  - Most patients with chronic ischemia and an implantable cardiac defibrillator 
      (ICD) for primary prevention do not experience therapies for ventricular 
      arrhythmias on follow-up. The present study aimed to identify independent 
      clinical, electrocardiographic, and echocardiographic predictors of death and 
      occurrence of ICD therapy in patients with chronic ischemic cardiomyopathy and 
      ICD for primary prevention. A total of 424 patients with chronic ischemic 
      cardiomyopathy, ejection fraction </= 35%, and New York Heart Association (NYHA) 
      class >/= II were recruited. All patients underwent echocardiography before ICD 
      insertion. Primary outcome was all-cause mortality; secondary outcome was 
      occurrence of appropriate ICD therapy on follow-up. Primary and secondary 
      outcomes occurred in 84 and 95 patients, respectively. Patients who died were 
      more likely to have diabetes (hazard ratio [HR] 1.67, 95% confidence interval 
      [CI] 1.00 to 2.79, p = 0.049), higher NYHA class (HR 1.96, 95% CI 1.15 to 3.33, p 
      = 0.013), lower peri-infarct strain on echocardiogram (HR 1.25, 95% CI 1.07 to 
      1.46, p = 0.005), and lower glomerular filtration rate (HR 1.01, 95% CI 1.00 to 
      1.03, p = 0.022). Only peri-infarct strain (HR 1.22, 95% CI 1.09 to 1.36, p < 
      0.001) predicted the occurrence of ICD therapy on follow-up. In conclusion, in 
      chronic ischemic patients with an ICD for primary prevention, the presence of 
      diabetes, renal dysfunction, higher NYHA class, and impaired peri-infarct zone 
      function were predictors of all-cause mortality. In contrast, only impaired 
      peri-infarct zone function determined the occurrence of appropriate ICD therapy 
      on follow-up.
CI  - Copyright (c) 2010 Elsevier Inc. All rights reserved.
FAU - Ng, Arnold C T
AU  - Ng AC
AD  - Department of Cardiology, Leiden University Medical Center, Leiden, The 
      Netherlands.
FAU - Bertini, Matteo
AU  - Bertini M
FAU - Borleffs, C Jan Willem
AU  - Borleffs CJ
FAU - Delgado, Victoria
AU  - Delgado V
FAU - Boersma, Eric
AU  - Boersma E
FAU - Piers, Sebastiaan R D
AU  - Piers SR
FAU - Thijssen, Joep
AU  - Thijssen J
FAU - Nucifora, Gaetano
AU  - Nucifora G
FAU - Shanks, Miriam
AU  - Shanks M
FAU - Ewe, See Hooi
AU  - Ewe SH
FAU - Biffi, Mauro
AU  - Biffi M
FAU - van de Veire, Nico R L
AU  - van de Veire NR
FAU - Leung, Dominic Y
AU  - Leung DY
FAU - Schalij, Martin J
AU  - Schalij MJ
FAU - Bax, Jeroen J
AU  - Bax JJ
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Randomized Controlled Trial
DEP - 20101014
PL  - United States
TA  - Am J Cardiol
JT  - The American journal of cardiology
JID - 0207277
SB  - IM
MH  - Aged
MH  - Death, Sudden, Cardiac/*epidemiology
MH  - *Defibrillators, Implantable
MH  - Electric Countershock/*methods
MH  - Electrocardiography
MH  - Female
MH  - Follow-Up Studies
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Myocardial Ischemia/complications/mortality/*therapy
MH  - Prospective Studies
MH  - Single-Blind Method
MH  - Survival Rate
MH  - Tachycardia, Ventricular/etiology/mortality/*prevention & control
MH  - Treatment Outcome
EDAT- 2010/11/26 06:00
MHDA- 2011/01/21 06:00
CRDT- 2010/11/25 06:00
PHST- 2010/07/05 00:00 [received]
PHST- 2010/07/21 00:00 [revised]
PHST- 2010/07/21 00:00 [accepted]
PHST- 2010/11/25 06:00 [entrez]
PHST- 2010/11/26 06:00 [pubmed]
PHST- 2011/01/21 06:00 [medline]
AID - S0002-9149(10)01499-2 [pii]
AID - 10.1016/j.amjcard.2010.07.029 [doi]
PST - ppublish
SO  - Am J Cardiol. 2010 Dec 1;106(11):1566-73. doi: 10.1016/j.amjcard.2010.07.029. 
      Epub 2010 Oct 14.