PMID- 21095010
OWN - NLM
STAT- MEDLINE
DCOM- 20110708
LR  - 20161125
IS  - 1549-4713 (Electronic)
IS  - 0161-6420 (Linking)
VI  - 118
IP  - 5
DP  - 2011 May
TI  - Vitreomacular interface in typical exudative age-related macular degeneration and 
      polypoidal choroidal vasculopathy.
PG  - 853-9
LID - 10.1016/j.ophtha.2010.09.001 [doi]
AB  - PURPOSE: To investigate the association in Japanese between posterior vitreous 
      attachment and the pathologies of typical age-related macular degeneration (AMD) 
      and polypoidal choroidal vasculopathy (PCV), 2 major forms of exudative AMD. 
      DESIGN: Retrospective observational case series. PARTICIPANTS: A total of 378 
      eyes from 302 subjects (132 with typical AMD, 126 with PCV, 120 controls) from 
      the University of Tokyo Hospital. METHODS: Posterior vitreous detachment (PVD) 
      and vitreomacular adhesion (VMA) were investigated by B-mode ultrasonography and 
      spectral-domain optical coherence tomography (SD-OCT), respectively. The greatest 
      linear dimension (GLD) of initial photodynamic therapy (PDT) in a subset of the 
      patients (n=92) receiving PDT was also investigated. MAIN OUTCOME MEASURES: 
      Number of eyes with complete PVD and with VMA. The GLD of initial PDT. RESULTS: 
      In typical AMD eyes, the frequency of complete PVD was significantly lower (63 
      [56.8%] of 111 eyes) than in the controls (52 [70.3%] of 74 eyes, risk ratio [RR] 
      0.76, P=0.021) and the frequency of VMA tended to be higher (14/115 [12.2%] in 
      typical AMD eyes and 6/86 [7.0%] in the controls, RR 2.15, P=0.099). The 
      frequency of complete PVD [77 [63.1%] of the 122 eyes] and VMA (9/108 [8.3%]) in 
      PCV eyes was the same as the controls (RR 0.91, P=0.415 and RR 1.29, P=0.615). In 
      patients with unilateral exudative AMD, the frequency of complete PVD was lower 
      in typical AMD eyes than in fellow eyes (odds ratio [OR] 0.111, P=0.026) and VMA 
      was observed in 7 (17.5%) and 3 (7.5%) typical AMD and fellow eyes, respectively 
      (OR 2.33, P=0.34), whereas in PCV eyes, the frequency of complete PVD was higher 
      (OR 8.00, P=0.045) and the frequency of VMA was the same as in the fellow eyes 
      (OR 0.80, P=1.00). The GLD of the eyes without complete PVD or with VMA was 
      significantly larger than that in the eyes with complete PVD in typical AMD eyes 
      (P=0.042) and the same as that in the eyes with complete PVD in PCV eyes 
      (P=0.67). CONCLUSIONS: There is an association between posterior vitreous 
      attachment and typical AMD. However, this association is not evident in PCV.
CI  - Copyright (c) 2011 American Academy of Ophthalmology. Published by Elsevier Inc. 
      All rights reserved.
FAU - Nomura, Yoko
AU  - Nomura Y
AD  - Department of Ophthalmology, University of Tokyo School of Medicine, Tokyo, 
      Japan.
FAU - Ueta, Takashi
AU  - Ueta T
FAU - Iriyama, Aya
AU  - Iriyama A
FAU - Inoue, Yuji
AU  - Inoue Y
FAU - Obata, Ryo
AU  - Obata R
FAU - Tamaki, Yasuhiro
AU  - Tamaki Y
FAU - Yamaguchi, Takuhiro
AU  - Yamaguchi T
FAU - Yanagi, Yasuo
AU  - Yanagi Y
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20101120
PL  - United States
TA  - Ophthalmology
JT  - Ophthalmology
JID - 7802443
RN  - IX6J1063HV (Indocyanine Green)
SB  - IM
MH  - Adhesiveness
MH  - Aged
MH  - Choroid/*blood supply
MH  - Exudates and Transudates
MH  - Female
MH  - Fluorescein Angiography
MH  - Humans
MH  - Incidence
MH  - Indocyanine Green
MH  - Macula Lutea/*physiology
MH  - Macular Degeneration/*complications/diagnosis/drug therapy
MH  - Male
MH  - Middle Aged
MH  - Peripheral Vascular Diseases/*complications/diagnosis/drug therapy
MH  - Photochemotherapy
MH  - Retrospective Studies
MH  - Tomography, Optical Coherence
MH  - Ultrasonography
MH  - Vitreous Body/*physiology
MH  - Vitreous Detachment/diagnostic imaging/*etiology
EDAT- 2010/11/26 06:00
MHDA- 2011/07/09 06:00
CRDT- 2010/11/25 06:00
PHST- 2010/03/06 00:00 [received]
PHST- 2010/09/01 00:00 [revised]
PHST- 2010/09/01 00:00 [accepted]
PHST- 2010/11/25 06:00 [entrez]
PHST- 2010/11/26 06:00 [pubmed]
PHST- 2011/07/09 06:00 [medline]
AID - S0161-6420(10)00943-7 [pii]
AID - 10.1016/j.ophtha.2010.09.001 [doi]
PST - ppublish
SO  - Ophthalmology. 2011 May;118(5):853-9. doi: 10.1016/j.ophtha.2010.09.001. Epub 
      2010 Nov 20.