PMID- 21096375
OWN - NLM
STAT- MEDLINE
DCOM- 20110406
LR  - 20200928
IS  - 2375-7477 (Print)
IS  - 2375-7477 (Linking)
VI  - 2010
DP  - 2010
TI  - Recognition and inhibition of dorsal horn nociceptive signals within a 
      closed-loop system.
PG  - 1535-8
LID - 10.1109/IEMBS.2010.5626830 [doi]
AB  - We implemented an integrated system that can acquire neuronal signals from spinal 
      cord dorsal horn neurons, wirelessly transmit the signals to a computer, and 
      recognize the nociceptive signals from three different mechanical stimuli (brush, 
      pressure and pinch). Positive peak detection method was chosen to distinguish 
      between signal spikes. The inter spike intervals (ISIs) were calculated from the 
      identified action potentials (APs) and fed into a numerical array called cluster. 
      When the sum of the ISIs in the cluster reached a critical level, the program 
      recognized the recorded signals as nociceptive inputs. The user has the 
      flexibility to tune both the cluster size and critical threshold for individual's 
      need to reach optimization in pain signal recognition. The program was integrated 
      with a wireless neurostimulator to form a feedback loop to recognize and inhibit 
      nociceptive signals.
FAU - Farajidavar, Aydin
AU  - Farajidavar A
AD  - Department of Bioengineering, University of Texas at Arlington, TX 76019, USA. 
      aydin.farajidavar@mavs.uta.edu
FAU - Hagains, Christopher E
AU  - Hagains CE
FAU - Peng, Yuan B
AU  - Peng YB
FAU - Behbehani, Khosrow
AU  - Behbehani K
FAU - Chiao, J-C
AU  - Chiao JC
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, Non-P.H.S.
PL  - United States
TA  - Annu Int Conf IEEE Eng Med Biol Soc
JT  - Annual International Conference of the IEEE Engineering in Medicine and Biology 
      Society. IEEE Engineering in Medicine and Biology Society. Annual International 
      Conference
JID - 101763872
SB  - IM
MH  - Animals
MH  - Biofeedback, Psychology/*instrumentation
MH  - Diagnosis, Computer-Assisted/instrumentation
MH  - Electric Stimulation Therapy/*instrumentation
MH  - Electrodes, Implanted
MH  - Electrodiagnosis/*instrumentation
MH  - Equipment Design
MH  - Equipment Failure Analysis
MH  - Male
MH  - Neural Inhibition
MH  - Pain/*diagnosis/physiopathology/*prevention & control
MH  - *Posterior Horn Cells
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - Telemetry/*instrumentation
MH  - Therapy, Computer-Assisted/instrumentation
EDAT- 2010/11/26 06:00
MHDA- 2011/04/07 06:00
CRDT- 2010/11/25 06:00
PHST- 2010/11/25 06:00 [entrez]
PHST- 2010/11/26 06:00 [pubmed]
PHST- 2011/04/07 06:00 [medline]
AID - 10.1109/IEMBS.2010.5626830 [doi]
PST - ppublish
SO  - Annu Int Conf IEEE Eng Med Biol Soc. 2010;2010:1535-8. doi: 
      10.1109/IEMBS.2010.5626830.